(S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester

Base Information

• Chemical Name: (S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester
• CAS No.: 870809-33-9
• Molecular Formula: C₂₅H₂₄O₅
• Molecular Weight: 404.463
• Mol file: 870809-33-9.mol

Synonyms:(S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester

Chemical Property of (S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester

There total 2 articles about (S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,5-bisbenzyloxy-2-methylbenzoic acid (127531-39-9) + (S)-Glycidyl tosylate (70987-78-9,6746-81-2) → (S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester (870809-33-9)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; at 40 ℃; for 5.5h; Reagent/catalyst;

Reference yield: 88.7%

4,5-bisbenzyloxy-2-methylbenzoic acid (127531-39-9) + (2s)-(+)-glycidyl 3-nitrobenzenesulfonate (115314-14-2) → (S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester (870809-33-9)

Guidance literature:

4,5-bisbenzyloxy-2-methylbenzoic acid; With sodium hydride; In 1-methyl-pyrrolidin-2-one; for 0.5h;

(2s)-(+)-glycidyl 3-nitrobenzenesulfonate; In 1-methyl-pyrrolidin-2-one; for 20h;

Reference yield: 56.5%

(S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester (870809-33-9) + oxalic acid (144-62-7,97993-78-7) + 2-Amino-2-methyl-1-propanol (124-68-5) → (S)-4,5-bis-benzyloxy-2-methyl-benzoic acid 2-hydroxy-3-(2-hydroxy-1,1-dimethyl-ethylamino)-propyl ester oxalate

Guidance literature:

(S)-4,5-bis-benzyloxy-2-methyl-benzoic acid oxiranylmethyl ester; 2-Amino-2-methyl-1-propanol; In acetonitrile; for 48h; Heating / reflux;

oxalic acid; In ethyl acetate;

upstream raw materials:

4,5-bisbenzyloxy-2-methylbenzoic acid

(2s)-(+)-glycidyl 3-nitrobenzenesulfonate

(S)-Glycidyl tosylate