870812-31-0Relevant articles and documents
CHEMICAL COMPOUNDS
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, (2012/02/15)
The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.
Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents
Eswaran, Sumesh,Adhikari, Airody Vasudeva,Pal, Nishith K.,Chowdhury, Imran H.
supporting information; experimental part, p. 1040 - 1044 (2010/06/14)
A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC2), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.
APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES
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Page/Page column 42, (2010/08/07)
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
BCL-2 INHIBITORS CONTAINING A ZINC BINDING MOIETY
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Page/Page column 59, (2009/04/25)
The present invention relates to Bcl-2 inhibitors and their use in the treatment of cell proliferative diseases such as cancer. The compounds of the invention may further act as HDAC inhibitors
BCL-2 INHIBITORS
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Page/Page column 45; 46, (2009/04/25)
The present invention relates to Bcl-2 inhibitors and their use in the treatment of cell proliferative diseases such as cancer.
ARYLSULFONAMIDE COMPOUNDS
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Page/Page column 34; 36-37, (2008/12/05)
The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mim
N-sulfonylcarboximidamide apoptosis promoters
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Page/Page column 12, (2008/06/13)
Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.