870812-29-6

Basic information

• Product Name: N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester
• Synonyms: N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester;[(1R)-3-(DiMethylaMino)-1-(hydroxyMethyl)-3-oxopropyl]carbaMic Acid PhenylMethyl Ester;CarbaMic acid, N-[(1R)-3-(diMethylaMino)-1-(hydroxyMethyl)-3-oxopropyl]-, phenylMethyl ester;Benzyl [(R)-4-(dimethylamino)-1-hydroxy-4-oxobutan-2-yl]carbamate
• CAS NO: 870812-29-6
• Molecular Formula: C₁₄H₂₀N₂O₄
• Molecular Weight: 280.3196
• Product Categories: Amines;Aromatics;Intermediates
• Mol File: 870812-29-6.mol

Chemical Properties

• Appearance: /
• Solubility: Chloroform, DMSO, Methanol
• CAS DataBase Reference: N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester(870812-29-6)
• EPA Substance Registry System: N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester(870812-29-6)

Safety Data

• Hazardous Substances Data: 870812-29-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester is used as an intermediate in the synthesis of N-sulfonylcarboximidamides. These compounds are of significant interest due to their ability to trigger cell death, making them potential candidates for the development of novel therapeutic agents targeting various diseases, including cancer.
As an intermediate, N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester plays a crucial role in the preparation of bioactive molecules with potential applications in the pharmaceutical industry. Its unique structure and reactivity enable the synthesis of a variety of N-sulfonylcarboximidamides, which can be further explored for their therapeutic potential.

Upstream product

• 78663-07-7 N-(benzyloxycarbonyl)-D-aspartic acid 
• 123673-31-4 (R)-3-(benzyloxycarbonylamino)-4-hydroxybutanoic acid 
• 75443-62-8 benzyl N-[(3R)-2,5-dioxotetrahydrofuran-3-yl]carbamate 
• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 
• 124-40-3 dimethyl amine 
• 118399-28-3 (R)-4-benzyloxycarbonylamino-4,5-dihydro-2(3H)-furanone 

Downstream Products

• 406233-35-0 4-(((1R)-3-(dimethylamino)-1-((phenylthio)methyl)propyl)amino)-3-nitrobenzenesulfonamide 
• 870812-31-0 (3R)-3-amino-N,N-dimethyl-4-(phenylthio)butanamide 
• 870812-32-1 (R)-N¹,N¹-dimethyl-4-(phenylthio)butane-1,3-diamine 
• 1027345-10-3 C₁₅H₂₂N₂O₆S 
• 870812-30-9 benzyl {(1R)-3-(dimethylamino)-3-oxo-1-[(phenylthio)methyl]propyl}carbamate 

Relevant articles and documents

CHEMICAL COMPOUNDS

The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.

APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

ARYLSULFONAMIDE COMPOUNDS

The invention relates generally to small molecules that mimic the biological activity of certain peptides and proteins, to compositions containing them and to their use. In particular, the invention relates to compounds of the general formula (I) that mim

N-sulfonylcarboximidamide apoptosis promoters

Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.