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TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE is a complex organic compound characterized by its diverse functional groups, including an ester group, a phenyl group, an ethyl group, and a hydrazine group. Its unique structure, composed of carbon, hydrogen, oxygen, and nitrogen, endows it with specific chemical properties that make it a valuable component in the synthesis of other complex molecules, particularly in the pharmaceutical industry. However, its toxicity and potential hazards are not well-documented, necessitating appropriate safety measures during handling.

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  • tert-butyl 2-(1-(4-(ethoxycarbonyl)phenyl)ethyl)hydrazine-1-carboxylate

    Cas No: 870822-88-1

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  • 870822-88-1 Structure
  • Basic information

    1. Product Name: TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE
    2. Synonyms: TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE
    3. CAS NO:870822-88-1
    4. Molecular Formula: C16H24N2O4
    5. Molecular Weight: 308.376
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 870822-88-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.097g/cm3
    6. Refractive Index: 1.512
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE(CAS DataBase Reference)
    10. NIST Chemistry Reference: TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE(870822-88-1)
    11. EPA Substance Registry System: TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE(870822-88-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 870822-88-1(Hazardous Substances Data)

870822-88-1 Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE is used as a synthetic intermediate for the development of complex pharmaceutical compounds due to its versatile structure and the presence of multiple functional groups that can be utilized in chemical reactions.
Used in Organic Synthesis:
TERT-BUTYL 2-(1-(4-(ETHOXYCARBONYL)PHENYL)ETHYL)HYDRAZINECARBOXYLATE is used as a building block in organic synthesis for the creation of various organic molecules, leveraging its unique structure and functional groups to form new compounds with potential applications in different fields.

Check Digit Verification of cas no

The CAS Registry Mumber 870822-88-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,0,8,2 and 2 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 870822-88:
(8*8)+(7*7)+(6*0)+(5*8)+(4*2)+(3*2)+(2*8)+(1*8)=191
191 % 10 = 1
So 870822-88-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H24N2O4/c1-6-21-14(19)13-9-7-12(8-10-13)11(2)17-18-15(20)22-16(3,4)5/h7-11,17H,6H2,1-5H3,(H,18,20)

870822-88-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 4-[1-[2-[(2-methylpropan-2-yl)oxycarbonyl]hydrazinyl]ethyl]benzoate

1.2 Other means of identification

Product number -
Other names tert-butyl 2-[1-[4-(ethoxycarbonyl)phenyl]ethyl]hydrazinecarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:870822-88-1 SDS

870822-88-1Relevant articles and documents

A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities

Shu, Shuangjie,Dai, Antao,Wang, Jiang,Wang, Bin,Feng, Yang,Li, Jia,Cai, Xiaoqing,Yang, Dehua,Ma, Dakota,Wang, Ming-Wei,Liu, Hong

, p. 1896 - 1908 (2018/03/12)

A novel series of 4-methyl substituted pyrazole derivatives were designed, synthesized and biologically evaluated as potent glucagon receptor (GCGR) antagonists. In this study, compounds 9q, 9r, 19d and 19e showed high GCGR binding (IC50 = 0.09 μM, 0.06 μM, 0.07 μM and 0.08 μM, respectively) and cyclic-adenosine monophosphate (cAMP) activities (IC50 = 0.22 μM, 0.26 μM, 0.44 μM and 0.46 μM, respectively) in cell-based assays. Most importantly, the docking experiment demonstrated that compound 9r formed extensive hydrophobic interactions with the receptor binding pocket, making it justifiable to further investigate the potential of becoming a GCGR antagonist.

Design, synthesis, structure-activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists

Shu, Shuangjie,Cai, Xiaoqing,Li, Jia,Feng, Yang,Dai, Antao,Wang, Jiang,Yang, Dehua,Wang, Ming-Wei,Liu, Hong

, p. 2852 - 2863 (2016/06/08)

Glucagon receptor antagonists possess a great potential for treatment of type 2 diabetes mellitus. A series of pyrazole-containing derivatives were designed, synthesized and evaluated by biological assays as glucagon receptor antagonists. Most of the compounds exhibited good in vitro efficacy. Two of them, compounds 17f and 17k, displayed relatively potent antagonist effects on glucagon receptors with IC50 values of 3.9 and 3.6 μM, respectively. The possible binding modes of 17f and 17k with the cognate receptor were explored by molecular docking simulation.

Discovery of a novel glucagon receptor antagonist N-[(4-{(1 S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1 H -pyrazol-1-yl]ethyl}phenyl) carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes

Xiong, Yusheng,Guo, Jian,Candelore, Mari R.,Liang, Rui,Miller, Corey,Dallas-Yang, Qing,Jiang, Guoqiang,McCann, Peggy E.,Qureshi, Sajjad A.,Tong, Xinchun,Xu, Shiyao Sherrie,Shang, Jackie,Vincent, Stella H.,Tota, Laurie M.,Wright, Michael J.,Yang, Xiaodong,Zhang, Bei B.,Tata, James R.,Parmee, Emma R.

experimental part, p. 6137 - 6148 (2012/09/07)

A potent, selective glucagon receptor antagonist 9m, N-[(4-{(1S)-1-[3-(3,5- dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl) carbonyl]-β-alanine, was discovered by optimization of a previously identified lead. Compound 9m is a reversible and competitive antagonist with high binding affinity (IC50 of 6.6 nM) and functional cAMP activity (IC50 of 15.7 nM). It is selective for glucagon receptor relative to other family B GPCRs, showing IC50 values of 1020 nM for GIPR, 9200 nM for PAC1, and >10000 nM for GLP-1R, VPAC1, and VPAC2. Compound 9m blunted glucagon-induced glucose elevation in hGCGR mice and rhesus monkeys. It also lowered ambient glucose levels in both acute and chronic mouse models: in hGCGR ob/ob mice it reduced glucose (AUC 0-6 h) by 32% and 39% at 3 and 10 mpk single doses, respectively. In hGCGR mice on a high fat diet, compound 9m at 3, and 10 mpk po in feed lowered blood glucose levels by 89% and 94% at day 10, respectively, relative to the difference between the vehicle control and lean hGCGR mice. On the basis of its favorable biological and DMPK properties, compound 9m (MK-0893) was selected for further preclinical and clinical evaluations.

Pyrazole derivatives, compositions containing such compounds and methods of use

-

Page/Page column 15, (2010/11/26)

Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE

-

Page/Page column 29, (2008/06/13)

The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes

Pyrazole derivatives, compositions containing such compounds and methods of use

-

Page/Page column 21, (2008/06/13)

Pyrazoles having a naphthyl group attached are disclosed. The compounds are useful for treating type 2 diabetes and related conditions. Pharmaceutical compositions and methods of treatment are also included.

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