870854-90-3Relevant academic research and scientific papers
Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase
Tipparaju, Suresh K.,Joyasawal, Sipak,Forrester, Sara,Mulhearn, Debbie C.,Pegan, Scott,Johnson, Michael E.,Mesecar, Andrew D.,Kozikowski, Alan P.
supporting information; experimental part, p. 3565 - 3569 (2009/04/10)
Enoyl-ACP reductase (ENR), the product of the FabI gene, from Bacillus anthracis (BaENR) is responsible for catalyzing the final step of bacterial fatty acid biosynthesis. A number of novel 2-pyridone derivatives were synthesized and shown to be potent inhibitors of BaENR.
A practical procedure for the selective N-alkylation of 4-alkoxy-2-pyridones and its use in a sulfone-mediated synthesis of N-methyl-4-methoxy-2-pyridone
Conreaux, David,Bossharth, Emmanuel,Monteiro, Nuno,Desbordes, Philippe,Balme, Geneviève
, p. 7917 - 7920 (2007/10/03)
It has been found that selective N-alkylation of 4-alkoxy-2-pyridones can be achieved under anhydrous, mild conditions with tetrabutylammonium iodide and potassium tert-butoxide being employed as the catalyst and the base, respectively. The procedure was applied to the preparation of 4-methoxy-1-methyl-2-pyridone, a valuable building block for heterocycle synthesis.
