87087-35-2Relevant academic research and scientific papers
Photodriven Transfer Hydrogenation of Olefins
Leow, Dasheng,Chen, Ying-Ho,Hung, Tzu-Hang,Su, Ying,Lin, Yi-Zhen
supporting information, p. 7347 - 7352 (2016/02/18)
An improved practical method for the photodriven diimide reduction of olefins was investigated. This catalyst-free procedure proceeds at ambient temperature, utilizes air as oxidant and a lower hydrazine loading, and produces inert nitrogen gas as the sole byproduct. Several functional groups were tolerated, and in some cases, the reaction was chemoselective. Challenging substrates such as cinnamate ester derivatives and trans-stilbene were reduced in excellent yields. The small amount of UVA rays emitted from a household compact fluorescent light bulb was proposed to enable the cis/trans isomerization of the diimide and to promote the loss of hydrogen from the diimide.
A bifunctional palladated rasta resin for Mizoroki-Heck reactions
Derible, Antoine,Yang, Yun-Chin,Toy, Patrick H.,Becht, Jean-Michel,Le Drian, Claude
, p. 4331 - 4333 (2014/07/22)
Bifunctional palladated rasta resins 2b and 2c bearing both phosphino and basic amino groups have been successfully used for Mizoroki-Heck reactions between aryl iodides and alkenes without adding a soluble base. We have also shown that 2c can be easily regenerated after reaction and reused. To the best of our knowledge, this work represents the first use of a bifunctional palladated polymer for a CC bond forming reaction.
Mizoroki-Heck reactions of methyl acrylate in presence of a palladated rasta resin
Derible, Antoine,Becht, Jean-Michel,Le Drian, Claude
, p. 4207 - 4209 (2013/07/26)
Mizoroki-Heck cross-couplings of aryl halides in the presence of a palladium catalyst supported on a rasta resin bearing diphenylphosphanyl ligands are reported. In particular, we show that tiny amounts of soluble palladium species leached from the polymeric support catalyze the reaction. A one-pot two steps preparation of alkenes from aryl bromides using a Finkelstein halogen exchange reaction is also described.
Highly effective recyclable palladium-catalyzed ligand-free heck reactions under aerobic conditions
Sun, Peng,Qu, Xiaoming,Li, Tingyi,Zhu, Yan,Yang, Hailong,Xing, Zeyong,Mao, Jincheng
supporting information; experimental part, p. 150 - 154 (2012/02/04)
An effective protocol was developed for the Heck coupling reactions between various aryl halides and olefins. In the presence of 2 mol% of Pd(OAc) 2, the desired products could be obtained in good yields under ligand-free and aerobic conditions. The catalytic system could be easily recycled for five times with high efficiency. Georg Thieme Verlag Stuttgart. New York.
Thiosemicarbazone Salicylaldiminato-Palladium(II)-Catalyzed Mizoroki-Heck reactions
Xie, Guanlei,Chellan, Prinessa,Mao, Jincheng,Chibale, Kelly,Smith, Gregory S.
scheme or table, p. 1641 - 1647 (2010/09/03)
Four tridentate thiosemicarbazone salicylaldiminato-palladium(II) complexes of the general formula [Pd(saltsc-R)PPh3] [saltsc = salicylaldehyde thiosemicarbazone; R = H (1), 3-tert-butyl (2), 3methoxy (3), 5-chloro (4)], have been evaluated as catalyst precursors for the Mizoroki-Heck coupling reaction between a variety of electron-rich and electron-poor aryl halides and olefins. The palladium complexes (0.1-1 mol% loading) were found to effectively catalyze these reactions with high yields being obtained when aryl iodides and aryl bromides were utilized. The effects of base, catalyst loading, reaction temperature and reaction time on the catalytic activity of the most active complex were also investigated.
AMINE COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 175, (2010/04/25)
Provided is a novel amine compound represented by the following formula (I) having a superior peripheral blood lymphocyte decreasing action and superior in the immunosuppressive action, rejection suppressive action and the like, which shows decreased side effects of, for example, bradycardia and the like, or a pharmaceutically acceptable acid addition salt thereof, or a hydrate thereof, or a solvate thereof. wherein each symbol is as defined in the specification.
Perfluoro-tagged, phosphine-free palladium nanoparticles supported on silica gel: Application to alkynylation of aryl halides, Suzuki-Miyaura cross-coupling, and Heck reactions under aerobic conditions
Bernini, Roberta,Cacchi, Sandro,Fabrizi, Giancarlo,Forte, Giovanni,Petrucci, Francesco,Prastaro, Alessandro,Niembro, Sandra,Shafir, Alexandr,Vallribera, Adelina
supporting information; experimental part, p. 150 - 158 (2010/05/18)
The utilization of perfluoro-tagged palladium nanoparticles immobilized on fluorous silica gel through fluorous-fluorous interactions (Pd np-A/FSG) or through covalent bonding to silica gel (Pd np-B) in the alkynylation of aryl halides, in the Suzuki-Miyaura cross-coupling, as well as in the Heck reaction between methyl acrylate and aryl iodides is described. The reactions are carried out under aerobic and phosphine-free conditions with excellent to quantitative product yields in each case. The catalysts are easily recovered and reused several times without significant loss of activity. The alkynylation of aryl halides (under copper-free conditions) and the Suzuki-Miyaura cross-coupling are carried out in water. The Heck reaction of methyl acrylate with aryl iodides is best performed in MeCN. The utilization of Pdnp-B in the synthesis of 2,3-disubstituted indoles from 2-(alkynyl)trifluoroacetanilides and aryl halides is also reported.
Regio- and stereoselective heck α-arylation of cinnamyl alcohols
Ambrogio, Ilaria,Cacchi, Sandro,Fabrizi, Giancarlo,Goggiamani, Antonella,Sgalla, Simona
experimental part, p. 620 - 624 (2009/07/11)
The Heck reaction of cinnamyl alcohols with aryl iodides has been investigated using n-Bu4NOAc as the base in toluene. Under these conditions, the reaction affords regio- and stereoselectively (Z)-2,3-diarylallylic alcohols in moderate to good yields. Experimental evidence suggests that the observed selectivity in formation of the vinylic substitution products is kinetic in origin under these conditions and that both the base and the solvent play a key role. Georg Thieme Verlag Stuttgart.
