871014-79-8Relevant articles and documents
Discovery of oxazole-based PDE4 inhibitors with picomolar potency
Kuang, Rongze,Shue, Ho-Jane,Xiao, Li,Blythin, David J.,Shih, Neng-Yang,Chen, Xiao,Gu, Danlin,Schwerdt, John,Lin, Ling,Ting, Pauline C.,Cao, Jianhua,Aslanian, Robert,Piwinski, John J.,Prelusky, Daniel,Wu, Ping,Zhang, Ji,Zhang, Xiang,Celly, Chander S.,Billah, Motasim,Wang, Peng
, p. 2594 - 2597 (2012)
Optimization of oxazole-based PDE4 inhibitors has led to the discovery of a series of quinolyl oxazoles, with 4-benzylcarboxamide and 5-α-aminoethyl groups which exhibit picomolar potency against PDE4. Selectivity profiles and in vivo biological activity are also reported.
