871095-00-0Relevant articles and documents
Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues
Sheddan, Neil A.,Mulzer, Johann
, p. 3101 - 3104 (2007/10/03)
A cross metathesis (CM) approach has been successfully applied to introduce fully functionalized ω-side chain appendages of various prostacyclin and prostaglandin analogues, resulting in high (E)-selectivities for the C13-C14 double bond and leading to the total syntheses of isocarbacyclin, 15R-TIC, carbacyclin, and PGF2α, and the formal syntheses of 15-deoxy-TIC and PGJ2.