871102-28-2Relevant academic research and scientific papers
Neighboring effect of the lactam functionality in select reactions of 6-azaspiro[4.5]decane-1,7-dione
Hilmey, David G.,Gallucci, Judith C.,Paquette, Leo A.
, p. 11000 - 11009 (2007/10/03)
The susceptibility of 6-azaspiro[4.5]decane-1,7-dione (4) to nucleophilic attack was evaluated. Although steric effects preclude the 1,2-addition of many reagents, more reactive lithium and Grignard species react. Attack from the direction syn to the lact
