871103-27-4Relevant articles and documents
Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) Reductase in Toxoplasma gondii
Stec, Jozef,Fomovska, Alina,Afanador, Gustavo A.,Muench, Stephen P.,Zhou, Ying,Lai, Bo-Shiun,ElBissati, Kamal,Hickman, Mark R.,Lee, Patty J.,Leed, Susan E.,Auschwitz, Jennifer M.,Sommervile, Caroline,Woods, Stuart,Roberts, Craig W.,Rice, David,Prigge, Sean T.,Mcleod, Rima,Kozikowski, Alan P.
, p. 1138 - 1160 (2013)
Through our focused effort to discover new and effective agents against toxoplasmosis, a structure-based drug design approach was used to develop a series of potent inhibitors of the enoyl-acyl carrier protein (ACP) reductase (ENR) enzyme in Toxoplasma go