448-53-3

Basic information

• Product Name: tris(3-fluoro phenyl)boroxine
• Synonyms: tris(3-fluoro phenyl)boroxine
• CAS NO: 448-53-3
• Molecular Weight: 365.72
• Mol File: 448-53-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: tris(3-fluoro phenyl)boroxine(CAS DataBase Reference)
• NIST Chemistry Reference: tris(3-fluoro phenyl)boroxine(448-53-3)
• EPA Substance Registry System: tris(3-fluoro phenyl)boroxine(448-53-3)

Safety Data

• Hazardous Substances Data: 448-53-3(Hazardous Substances Data)

Upstream product

• 768-35-4 3-fluorophenylboronic acid 
• 688-74-4 boric acid tributyl ester 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 

Downstream Products

• 21099-60-5 3,3'-diflurodiphenyl sulfide 
• 1204677-76-8 1-(benzylsulfonyl)-3-fluorobenzene 
• 1229514-03-7 (3-fluorophenyl)-2,3-dichlorophenylsulfide 
• 1210812-12-6 1-fluoro-3-(4-chlorophenylsulfanyl)benzene 
• 2249-00-5 (3-fluorophenyl)-4-nitrophenylsulfide 
• 1229513-86-3 (3-fluorophenyl)-4-tolylsulfide 
• 78156-73-7 (4-bromophenyl)-3-fluorophenylsulfide 
• 1229514-06-0 (3-fluorophenyl)-4-hydroxyphenylsulfide 
• 1053621-87-6 (3-fluorophenyl)-4-fluorophenylsulfide 
• 1229513-97-6 (3-fluorophenyl)-2,4-dimethylphenylsulfide 
• 40154-91-4 1-fluoro-3-phenylsulfanyl-benzene 
• 1229514-09-3 (3-fluorophenyl)-4-aminophenylsulfide 
• 1229514-00-4 (3-fluorophenyl)-4-isopropylphenylsulfide 
• 1629-09-0 3-fluoro-N-phenylbenzamide 

Relevant articles and documents

Scalable synthesis of oxazolones from propargylic alcohols through multistep palladium(II) catalysis: β-selective oxidative heck coupling of cyclic sulfonyl enamides and aryl boroxines

A whale of a scale: The title oxidative Heck coupling proceeded with unusual β selectivity to generate a variety of branched substituted oxazolones (see scheme; Ts=p-toluenesulfonyl). The three-step synthesis from readily available starting materials with a simple palladium catalyst and inexpensive reagents could be carried out in a single reaction vessel or scaled up for the preparation of large amounts of these amino acid precursors. Copyright

Palladium(II)-Catalyzed Enantioselective Synthesis of α-(Trifluoromethyl)arylmethylamines

We describe a method for the synthesis of α-(trifluoromethyl)arylmethylamines that consists of the palladium(II)-catalyzed addition of arylboroxines to imines derived from trifluoroacetaldehyde. Palladium acetate is used as a catalyst with electron-neutral or electron-rich arylboroxines, and it was found that addition of an ammonium or silver salt was crucial to promote the reaction of electron-poor boroxines. With (S)-t-Bu-PyOX as the chiral ligand, this method delivers a variety of α-trifluoromethylated amines in 57-91% yield and with greater than 92% ee in most cases.

Diastereoselective synthesis of vicinally bis(trifluoromethylated) alkylboron compounds through successive insertions of 2,2,2-trifluorodiazoethane

The usefulness of embedded CF3 substituents within organic substructures necessitates the development of diverse methods for incorporating this functional group. A recently reported route to α-trifluoromethylated alkylboron compounds by an α-transfer mechanism has now been extended to the synthesis of unprecedented, vicinally ditrifluoromethylated alkylboron compounds in a diastereoselective fashion. The utility of these products is highlighted by conversion of the C-B bond into other functional groups.