87121-56-0

Upstream product

• 87121-55-9 1-(2-hydrazino-4-pyridyl)-1-ethylenedioxypropane 
• 87121-54-8 1-(2-chloro-4-pyridyl)-1-ethylenedioxypropane 
• 87121-53-7 1-(2-chloropyridin-4-yl)propan-1-one 
• 33252-30-1 2-chloro-4-pyridinenitrile 
• 87121-57-1 1-(2-amino-4-pyridyl)-1-ethylenedioxypropane 

Relevant academic research and scientific papers

The synthesis of 2-amino-4-(4-imidazolyl)pyridines

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines, potential histamine H2 antagonists, is described. The synthesis is based on the Neber rearrangement of 1-(4-pyridyl)-l-alkanone oxime O-tosylates to the appropriate α-aminoketones or α-aminoketals, which are then converted to the corresponding imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of chloride by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.