87121-53-7

Basic information

• Product Name: 2-CHLORO-4-PROPIONYLPYRIDINE
• Synonyms: 2-CHLORO-4-PROPIONYLPYRIDINE
• CAS NO: 87121-53-7
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.61
• Mol File: 87121-53-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 283.252°C at 760 mmHg
• Flash Point: 125.107°C
• Appearance: /
• Density: 1.189g/cm³
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 2-CHLORO-4-PROPIONYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4-PROPIONYLPYRIDINE(87121-53-7)
• EPA Substance Registry System: 2-CHLORO-4-PROPIONYLPYRIDINE(87121-53-7)

Safety Data

• Hazardous Substances Data: 87121-53-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8ClNO/c1-2-7(11)6-3-4-10-8(9)5-6/h3-5H,2H2,1H3

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 925-90-6 ethylmagnesium bromide 
• 1220126-90-8 1-(2-(methylsulfonyl)pyridin-4-yl)propan-1-one 
• 20277-69-4 sodium methansulfinate 
• 6313-54-8 2-chloroisonicotinic acid, 
• 2386-64-3 ethylmagnesium chloride 

Downstream Products

• 387862-46-6 (S)-5-Ethyl-5-hydroxy-2,5,6,9-tetrahydro-8-oxa-2-aza-benzocycloheptene-1,7-dione 
• 186668-50-8 1-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-1-propanone 
• 880767-52-2 3-benzyloxymethyl-4-(2-ethyl[1,3]dioxolan-2-yl)-2-methoxypyridine 
• 186668-51-9 tert-butyl 3-{3-[(benzyloxy)methyl]-2-methoxy-4-pyridinyl}-3-hydroxypentanoate 
• 221054-70-2 (+)-(5R)-5-Ethyl-5-hydroxy-2,5,6,9-tetrahydro-8-oxa-2-aza-benzocycloheptene-1,7-dione 
• 220998-02-7 (R)-3-(3-benzyloxymethyl-2-methoxypyridin-4-yl)-3-hydroxypentanoic acid 

Relevant articles and documents

Development of an enantioselective hydrogenation route to (S)-1-(2-(methylsulfonyl)pyridin-4-yl)propan-1-amine

A highly enantioselective enamide hydrogenation route to the title amine was developed. Highlights of the synthesis include an efficient two-step synthesis of a 2-sulfonyl 4-pyridyl ethyl ketone, a simple enamide synthesis by direct condensation of propionamide with a ketone, catalytic asymmetric enamide hydrogenation employing the in-house-developed ligand MeO-BIBOP, and a mild epimerization-free deprotection of a propionamide using Koenig's procedure.

Practical formal total syntheses of the homocamptothecin derivative and anticancer agent diflomotecan via asymmetric acetate aldol additions to pyridine ketone substrates

(Chemical Equation Presented) Two practical, efficient, and scalable asymmetric routes to DE ring fragment 7, a key building block in the synthesis of the homocamptothecin derivative diflomotecan 4, are described. The "acetal route" starts from 2-chloro-4

New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them

A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.