871249-28-4Relevant academic research and scientific papers
O-Aminoalkyl-O-trimethyl-2,3-dehydrosilybins: Synthesis and in vitro effects towards prostate cancer cells
Vue, Bao,Zhang, Sheng,Vignau, Andre,Chen, Guanglin,Zhang, Xiaojie,Diaz, William,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong
, (2018)
As part of our ongoing silybin project, this study aims to introduce a basic nitrogen-containing group to 7-OH of 3,5,20-O-trimethyl-2,3-dehydrosilybin or 3-OH of 5,7,20-O-trimethyl- 2,3-dehydrosilybin via an appropriate linker for in vitro evaluation as
5- or/and 20-O-alkyl-2,3-dehydrosilybins: Synthesis and biological profiles on prostate cancer cell models
Vue, Bao,Zhang, Xiaojie,Lee, Timmy,Nair, Nandini,Zhang, Sheng,Chen, Guanglin,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong
, (2017)
To investigate the effects of alkylation at 5-OH and 20-OH of 2,3-dehydrosilybin on prostate cancer cell proliferation, the synthetic approaches to 5- or/and 20-O-alkyl-2,3-dehydrosilybins, through a multi-step sequence from commercially available silybin
3-O-Alkyl-2,3-dehydrosilibinins: Two synthetic approaches and in vitro effects toward prostate cancer cells
Zhang, Sheng,Vue, Bao,Huang, Michael,Zhang, Xiaojie,Lee, Timmy,Chen, Guanglin,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong
, p. 3226 - 3231 (2016/07/12)
Eight 3-O-alkyl-2,3-dehydrosilibinins have been synthesized from commercially available silibinin through two synthetic approaches. A one-pot reaction, starting with aerobic oxidation of silibinin followed by direct alkylation of the phenolic hydroxyl gro
Synthesis and antiangiogenic activity of new silybin galloyl esters
Ga?ák, Radek,Valentová, Kate?ina,Fuksová, Kate?ina,Marhol, Petr,Kuzma, Marek,Medina, Miguel ángel,Oborná, Ivana,Ulrichová, Jitka,K?en, Vladimír
scheme or table, p. 7397 - 7407 (2011/12/14)
The synthesis of various silybin monogalloyl esters was developed, and their antiangiogenic activities were evaluated in a variety of in vitro tests with human umbilical vein endothelial cells (HUVECs). A structure-activity relationship (SAR) study found
