87126-68-9Relevant academic research and scientific papers
Synthesis and Anticonvulsant Activity of 7-Oxabicycloheptane Derivatives: Part II - N-Alkyl, N-Aryl and N-Heteroaryl Derivatives of 3,6-Epoxyhexahydrophthalic Acid Amide
Joshi, Balawant S.,David, Joy,Gawad, Dilip H.
, p. 136 - 139 (2007/10/02)
A series of (fifty) N-substituted 3,6-epoxyhexahydrophthalic acid amides have been prepared by the reaction of exo-cis-7-oxabicycloheptane-2,3-dicarboxylic anhydride with primary amines in benzene.Many of the compounds show anticonvulsant activity against electroshock, metrazol, strychnine and picrotoxin induced convulsions.Several compounds are found to be superior to ethosuximide and sodium valproate in anti-electroshock and antimetrazol test systems.
