871307-18-5 Usage
Uses
Used in Pharmaceutical Industry:
4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile is used as a Tpl2 kinase inhibitor for inhibiting tumor progression and inflammation. Its selectivity for Tpl2 over other kinases makes it a potential therapeutic agent for various diseases, including cancer and inflammatory disorders.
Used in Cancer Research:
4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile is used as a research tool for studying the role of Tpl2 kinase in cancer progression and inflammation. Its ability to inhibit LPS-induced TNF-α production and enhance differentiation induced by calcitriol in leukemia cells makes it a valuable compound for investigating the underlying mechanisms of these processes.
Used in Drug Discovery:
4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile is used as a lead compound in drug discovery for the development of novel Tpl2 kinase inhibitors. Its selectivity and inhibitory activity against Tpl2 kinase make it a promising candidate for further optimization and development into a therapeutic agent for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 871307-18-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,3,0 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 871307-18:
(8*8)+(7*7)+(6*1)+(5*3)+(4*0)+(3*7)+(2*1)+(1*8)=165
165 % 10 = 5
So 871307-18-5 is a valid CAS Registry Number.
InChI:InChI=1/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
871307-18-5Relevant academic research and scientific papers
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles
Kaila, Neelu,Green, Neal,Li, Huan-Qiu,Hu, Yonghan,Janz, Kristin,Gavrin, Lori Krim,Thomason, Jennifer,Tam, Steve,Powell, Dennis,Cuozzo, John,Hall, J. Perry,Telliez, Jean-Baptiste,Hsu, Sang,Nickerson-Nutter, Cheryl,Wang, Qin,Lin, Lih-Ling
, p. 6425 - 6442 (2008/04/05)
We have previously reported the discovery and initial SAR of the [1,7]naphthyridine-3-carbonitriles and quinoline-3-carbonitriles as Tumor Progression Loci-2 (Tpl2) kinase inhibitors. In this paper, we report new SAR efforts which have led to the identifi
4, 6-DIAMINO-[1,7] NAPHTHYRIDINE-3-CARBONITRILE INHIBITORS OF TPL2 KINASE AND METHODS OF MAKING AND USING THE SAME
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Page/Page column 18-19, (2010/11/25)
The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, m and n are defined as described herein. The inventio
Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure-activity relationships
Gavrin, Lori Krim,Green, Neal,Hu, Yonghan,Janz, Kristin,Kaila, Neelu,Li, Huan-Qiu,Tam, Steve Y.,Thomason, Jennifer R.,Gopalsamy, Ariamala,Ciszewski, Greg,Cuozzo, John W.,Hall, J. Perry,Hsu, Sang,Telliez, Jean-Baptiste,Lin, Lih-Ling
, p. 5288 - 5292 (2007/10/03)
The synthesis and structure-activity studies of a series of 6-substituted-4-anilino-[1,7]-naphthyridine-3-carbonitriles as inhibitors of Tpl2 kinase are described. The early exploratory work described here may lead to the discovery of compounds with signi
