871332-75-1 Usage
Uses
Used in Organic Synthesis:
4-CHLORO-3-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID is used as a reagent in Suzuki coupling reactions for the formation of carbon-carbon bonds, which is crucial for constructing complex organic molecules and advancing chemical research.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-CHLORO-3-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID serves as a key intermediate in the development of new drugs, contributing to the discovery and synthesis of potential therapeutic agents.
Used in Material Science:
4-CHLORO-3-(PYRROLIDINE-1-CARBONYL)PHENYLBORONIC ACID is utilized in the production of advanced materials, where its unique chemical properties can enhance material performance and contribute to the creation of innovative products in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 871332-75-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,3,3 and 2 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 871332-75:
(8*8)+(7*7)+(6*1)+(5*3)+(4*3)+(3*2)+(2*7)+(1*5)=171
171 % 10 = 1
So 871332-75-1 is a valid CAS Registry Number.
871332-75-1Relevant academic research and scientific papers
A robust three-step telescoped synthesis of electron-deficient amide substituted arylboronic acids
Zhu, Jason,Razler, Thomas M.,Xu, Zhongmin,Conlon, David A.,Sortore, Eric W.,Fritz, Alan W.,Demerzhan, Roman,Sweeney, Jason T.
scheme or table, p. 438 - 442 (2012/02/03)
A robust three-step telescoped process for the preparation of electron-deficient amide-substituted arylboronic acids from readily available bromobenzoic acids has been developed. An EDC-HOBT-promoted amide formation of a bromobenzoic acid was followed by subjection of the product stream to a palladium-mediated cross-coupling with B2(pin)2. The resultant mixture of the arylboronate ester and arylboronic acid was directly treated with NaIO4, followed by a heptane-MeTHF crystallization, to cleanly afford the corresponding arylboronic acid in good yield. This general procedure was used to synthesize electron-deficient amide-substituted arylboronic acids with a diverse array of electron-withdrawing substituents.
