871335-85-2

Usage

Uses

Used in Pharmaceutical Research and Drug Development:
4-chloro-3-Methyl-1H-pyrazolo[3,4-d]pyriMidine is used as a building block in the synthesis of new drugs. Its role in creating novel compounds is crucial for the advancement of medicinal chemistry.
Used in Medicinal Chemistry:
4-chloro-3-Methyl-1H-pyrazolo[3,4-d]pyriMidine is used as a compound with potential therapeutic uses. Its properties and interactions with other molecules and biological systems are being actively researched to further understand its potential applications in treating various diseases and conditions.

Upstream product

• 2942-47-4 3-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one 
• 60025-06-1 1-(4,6-dichloropyrimidine-5-yl)ethane-1-one 
• 302-01-2 hydrazine 
• 2942-47-4 3-Methyl-4-hydroxypyrazolo<3,4-d>pyrimidin 
• 60025-05-0 4,6-dichloro-5-(α-hydroxyethyl)pyrimidine 
• 5305-40-8 2,6-dichloro-pyrimidine carbaldehyde 

Downstream Products

• 87412-89-3 4-chloro-1,3-dimethylpyrazolo<3,4-d>pyrimidine 
• 1304723-84-9 C₂₉H₄₃N₇O₄S 

Relevant academic research and scientific papers

1H-PYRAZOLO[3,4-D]PYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PLATINUM-RESISTANT CANCER

The invention relates to compounds of formula (I) and related compounds and their use in the treatment of cancer, especially platinum resistant cancer. The invention also provides a treatment comprising administration of a compound of formula (I) and a pl

Heterocyclic Compounds Useful as RAF Kinase Inhibitors

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES

Disclosed are novel pyrazolo[3,4-d]pyrimidine derivatives that are inhibitors of Raf kinase. These compounds and their pharmaceutically-acceptable salts and esters are anti-proliferative agents useful in the treatment or control of proliferative disorders such as solid tumors, in particular breast tumor, colon tumor, lung tumor, prostate tumor, and melanoma. Also disclosed are a composition and a unit dose formulation comprising such a compound, or a pharmaceutically-acceptable salt or ester thereof, methods for making such compounds, and methods for using such compounds, or their pharmaceutically-acceptable salts or esters, in the treatment of proliferative disorders.

AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS

The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein: A is a moiety of formula (Il) and to pharmaceutically acceptable salts and solvates thereof, wherein X, Z, D, E, V, W, Y, R1, R2, R5, R6, L, and u are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula I to a patient in need thereof, and to compositions for treating such disorders which contain the compounds of formula (I). The invention also relates to methods of making the compounds of formula (I).

KINASE MODULATORS AND METHODS OF USE

The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.