87412-89-3

Usage

Uses

Used in Pharmaceutical Research:
4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is used as a phosphodiesterase inhibitor for the study of signal transduction pathways and the regulation of cyclic nucleotides such as cAMP and cGMP in the body.
Used in Treatment of Asthma:
4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is used as a potential therapeutic agent for the treatment of asthma, as its phosphodiesterase inhibitory action can help improve lung function and reduce inflammation.
Used in Cardiovascular Disease Treatment:
4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is used as a potential therapeutic agent for the treatment of cardiovascular diseases, as its ability to regulate cyclic nucleotides may help improve blood flow and reduce the risk of heart-related complications.
Used in Erectile Dysfunction Treatment:
4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is used as a potential therapeutic agent for the treatment of erectile dysfunction, as its phosphodiesterase inhibitory action can help improve blood flow to the genital area and enhance erectile function.
Used as a Reference Standard in Analytical Chemistry:
4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine is used as a reference standard in analytical chemistry for the accurate determination of its properties and for the development of analytical methods for its detection and quantification.
Used in Anti-inflammatory and Immunosuppressant Research:
4-Chloro-1,3-dimethyl-1H-pyrazolo[3,4-d]pyrimidine has been investigated for its potential as an anti-inflammatory and immunosuppressant agent, as its phosphodiesterase inhibitory action may help reduce inflammation and modulate immune responses in various conditions.

Upstream product

• 87412-86-0 1,5-dihydro-1,3-dimethyl-4H-pyrazolo<3,4-d>pyrimidin-4-one 
• 101080-17-5 5-amino-1,3-dimethyl-1H-pyrazole-4-carboxamide 
• 344438-79-5 N-(1,3-dimethylpyrazolo<3,4-d>pyrimidin-4-yl)diacetamide 
• 87412-85-9 N-(1,3-dimethylpyrazolo<3,4-d>pyrimidin-4-yl)acetamide 
• 5346-58-7 4-amino-1,3-dimethyl-1H-pyrazolo<3,4-d>pyrimidine 
• 871335-85-2 4-chloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF

Provided herein are small molecule modulators of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Heterocyclic Compounds Useful as RAF Kinase Inhibitors

The present invention provides compounds useful as inhibitors of Raf protein kinase. The present invention also provides compositions thereof, and methods of treating Raf-mediated diseases.

PYRAZOLO[3,4-d]PYRIMIDINE DERIVATIVES

Disclosed are novel pyrazolo[3,4-d]pyrimidine derivatives that are inhibitors of Raf kinase. These compounds and their pharmaceutically-acceptable salts and esters are anti-proliferative agents useful in the treatment or control of proliferative disorders such as solid tumors, in particular breast tumor, colon tumor, lung tumor, prostate tumor, and melanoma. Also disclosed are a composition and a unit dose formulation comprising such a compound, or a pharmaceutically-acceptable salt or ester thereof, methods for making such compounds, and methods for using such compounds, or their pharmaceutically-acceptable salts or esters, in the treatment of proliferative disorders.

Aryl Coupling Reactions of Pyrazolopyrimidin-4-yl Radicals

4-Arylpyrazolopyrimidines (4) were the subjects of a synthetic investigation in order to evaluate their biological activity.Attempts to prepare 4 from 4-aminopyrazolopyrimidines (5) via classical Gomberg-Bachmann-Hey aryl coupling conditions failed.Conversion of 5 to 4 was accomplished by diazotiazation of 5 using alkyl nitrites with an acid catalyst in aromatic solvents.Isomer distribution of the aryl-coupled products 4 was that predicted for a radical intermediate (ortho > meta ca. para); isomer structures were assigned by a detailed 1H NMR analysis.Unusual fragmentation products 17 and 18 were isolated during the course of investigations.These oxadiazoles probably arise from collapse of intermediate pyrazolopyrimidin-4-yl radicals 15.