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871339-34-3

1,1-dimethylethyl 4-[5-chloro-2-methyl-3-(3-oxopropyl)phenyl]piperazine-1-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1,1-dimethylethyl 4-[5-chloro-2-methyl-3-(3-oxopropyl)phenyl]piperazine-1-carboxylate

    Cas No: 871339-34-3

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  • 871339-34-3 Structure

  • Basic information

    1. Product Name: 1,1-dimethylethyl 4-[5-chloro-2-methyl-3-(3-oxopropyl)phenyl]piperazine-1-carboxylate
    2. Synonyms: 1,1-dimethylethyl 4-[5-chloro-2-methyl-3-(3-oxopropyl)phenyl]piperazine-1-carboxylate
    3. CAS NO:871339-34-3
    4. Molecular Formula:
    5. Molecular Weight: 366.888
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 871339-34-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 1,1-dimethylethyl 4-[5-chloro-2-methyl-3-(3-oxopropyl)phenyl]piperazine-1-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1,1-dimethylethyl 4-[5-chloro-2-methyl-3-(3-oxopropyl)phenyl]piperazine-1-carboxylate(871339-34-3)
    11. EPA Substance Registry System: 1,1-dimethylethyl 4-[5-chloro-2-methyl-3-(3-oxopropyl)phenyl]piperazine-1-carboxylate(871339-34-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 871339-34-3(Hazardous Substances Data)

871339-34-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 871339-34-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,3,3 and 9 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 871339-34:
(8*8)+(7*7)+(6*1)+(5*3)+(4*3)+(3*9)+(2*3)+(1*4)=183
183 % 10 = 3
So 871339-34-3 is a valid CAS Registry Number.

871339-34-3Relevant articles and documents

Design and evaluation of a series of pyrazolopyrimidines as p70S6K inhibitors

Bussenius, Joerg,Anand, Neel K.,Blazey, Charles M.,Bowles, Owen J.,Bannen, Lynne Canne,Chan, Diva S.-M.,Chen, Baili,Co, Erick W.,Costanzo, Simona,Defina, Steven C.,Dubenko, Larisa,Engst, Stefan,Franzini, Maurizio,Huang, Ping,Jammalamadaka, Vasu,Khoury, Richard G.,Kim, Moon H.,Klein, Rhett R.,Laird, Douglas,Le, Donna T.,Mac, Morrison B.,Matthews, David J.,Markby, David,Miller, Nicole,Nuss, John M.,Parks, Jason J.,Tsang, Tsze H.,Tsuhako, Amy L.,Wang, Yong,Xu, Wei,Rice, Kenneth D.

, p. 2283 - 2286 (2012/05/04)

The 70-kDa ribosomal protein S6 kinase (p70S6K) is part of the PI3K/AKT/mTOR pathway and has been implicated in cancer. High throughput screening versus p70S6K led to the identification of aminopyrimidine 3a as active inhibitor. Lead optimization of 3a resulted in highly potent, selective, and orally bioavailable pyrazolopyrimidines. In this manuscript we report the structure-activity relationship of this series and pharmacokinetic, pharmacodynamic, and efficacy data of the lead compound 13c.

KINASE MODULATORS AND METHODS OF USE

-

, (2010/02/15)

The present invention relates to compounds of the Formula I and II wherein R, R21, R25-R33, m, n, X21-X23, and Q1 are defined herein. The compounds modulate protein kinase enzymatic activity to modulate cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly p70S6 and/or Akt kinases. Methods of using and preparing the compounds, and pharmaceutical compositions thereof, to treat kinase-dependent diseases and conditions are also an aspect of the invention.

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