87135-05-5Relevant academic research and scientific papers
Guanidine and 2-aminoimidazoline aromatic derivatives as α2-adrenoceptor antagonists, 1: Toward new antidepressants with heteroatomic linkers
Rodriguez, Fernando,Rozas, Isabel,Ortega, Jorge E.,Meana, J. Javier,Callado, Luis F.
, p. 4516 - 4527 (2008/03/12)
The efficient preparation and pharmacological characterization of different families of (bis)guanidine and (bis)2-aminoimidazoline derivatives ("twin" and "half" molecules) as potential α2-adrenoceptor antagonists for the treatment of depressio
Effect of 1,4-dioxanyl substitution on the adrenergic activity of some standard α-adrenoreceptor agents
Chapleo, Christopher B.,Doxey, John C.,Myers, Peter L.,Myers, Malcolm,Smith, Colin F. C.,Stillings, Michael R.
, p. 619 - 622 (2007/10/02)
A preliminary communication reported on the pharmacology of the potent partial α2-agonist (2-(1,4-benzodioxan-6-ylamino)-2-imidazoline, a 1,4-dioxan derivative of clonidine.Its degree of agonism/antagonism depended upon the peripheral or central α2-adrenoreceptor system studied.It was of interest to discover whether a similar substitution of the 1,4-dioxan moiety in other standard α-adrenergic agents would similary produce high affinity compounds of complex pharmacological profile.The same substitution when introduced into guanfacine, fenmetazole and tolazoline resulted in unpredictable changes in profile with a reduction in α-affinity. - α2-adrenoreceptors/antagonism/agonism/clonidine derivatives/1,4-dioxan derivatives
