871367-14-5

Basic information

• Product Name: 2(3H)-BENZOXAZOLONE, 7-BROMO-
• Synonyms: 2(3H)-BENZOXAZOLONE, 7-BROMO-;7-BroMobenzo[d]oxazol-2(3H)-one;7-Bromo-3H-benzooxazol-2-one
• CAS NO: 871367-14-5
• Molecular Formula: C7H4BrNO2
• Molecular Weight: 214.02
• EINECS: 200-589-5
• Mol File: 871367-14-5.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Density: 1.809g/cm³
• Refractive Index: 1.628
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2(3H)-BENZOXAZOLONE, 7-BROMO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-BENZOXAZOLONE, 7-BROMO-(871367-14-5)
• EPA Substance Registry System: 2(3H)-BENZOXAZOLONE, 7-BROMO-(871367-14-5)

Safety Data

• Hazardous Substances Data: 871367-14-5(Hazardous Substances Data)

Usage

Molecular Weight

214.04 g/mol

Structure

A bicyclic compound consisting of a benzene ring fused to a five-membered oxazole ring, with a bromine atom at the 7th position.

+ Appearance

White or pale yellow crystalline solid

+ Melting Point

142-146°C

+ Solubility

Slightly soluble in water, soluble in common organic solvents such as ethanol, methanol, and acetone.

+ Reactivity

The presence of the bromine atom at the 7th position makes the compound more reactive towards nucleophilic substitution reactions.

+ Functional Groups

The compound contains a lactone ring, an oxazole ring, and a bromine atom.

Biological Activities

The benzoxazolone family of compounds is known for its diverse biological activities, including antitumor, anti-inflammatory, and antimicrobial properties.

+ Pharmaceutical Industry

The compound has potential as a drug candidate for the treatment of various diseases due to its ability to modulate biological pathways.

+ Agrochemical Industry

The compound may be used as a pesticide or herbicide due to its ability to disrupt the growth and development of plants.

+ Materials Science

The compound's structural versatility may make it useful in the development of new materials with unique properties.

Research Interest

2(3H)-benzoxazolone, 7-bromohas shown promise in drug discovery and development, making it an intriguing target for further research and investigation.

InChI:InChI=1/C7H4BrNO2/c8-4-2-1-3-5-6(4)11-7(10)9-5/h1-3H,(H,9,10)

Upstream product

• 28165-50-6 2-amino-6-bromophenol 
• 530-62-1 1,1'-carbonyldiimidazole 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 3883-95-2 3-bromosalicylic acid 
• 1319081-99-6 3-bromo-2-hydroxybenzoyl azide 
• 1261615-73-9 3-bromo-2-hydroxybenzoyl chloride 
• 81282-60-2 7-aminobenzo[d]oxazol-2(3H)-one 

Relevant articles and documents

Structure, preparation method and application of a series of benzoxazolone derivatives

The invention discloses a structure, a preparation method and an application of a series of benzoxazolone derivatives, and particularly provides a benzoxazolone compound structure shown as a compoundI, a synthesis method, and an application of pharmaceutically acceptable salt or a mixture of the pharmaceutically acceptable salt in preparation of drugs for preventing and/or treating diabetic complications. The compounds are used as aldose reductase inhibitors and antioxidants, and also have the effect of reducing blood sugar. The compound can reduce blood sugar, inhibit the activity of aldosereductase, scavenge free radicals, inhibit the generation of lipid peroxide and improve the content of glutathione and the activity of superoxide dismutase, so that the urine protein level is reduced,and the effect of preventing and/or treating diabetic complications, especially diabetic nephropathy, is achieved. The invention also provides a pharmaceutical composition containing the compound andhaving the effect of preventing and/or treating diabetic complications; wherein X is a single bond, or is -CH=CH- and the R1 is hydrogen, hydroxyl, methoxyl or trifluoromethyl, and R2 is hydrogen, methoxyl or hydroxyl.

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

Novel benzoxazolone compound

PROBLEM TO BE SOLVED: To provide a therapeutic agent for diseases such as neuropathic pain, nociceptive pain, inflammatory pain, small diameter fiber neuropathy, erythromelalgia, paroxysmal extreme pain disorder, dysuria or multiple sclerosis. SOLUTION: There is provided a benzoxazolone compound represented by the formula (1) or a pharmaceutically acceptable salt. (1), where R1 and R2 are each independently H or C1-6 alkyl, where the alkyl may be substituted by hydroxy, C1-4 alkylsulfonyl, aminocarbonyl or 4 to 7-membered heterocycloalkyl, or the like, L is C1-6 alkylene, R3 is C1-6 alkyl, C3-7 cycloalkyl, where the cycloalkyl may be substituted by halogen or hydroxy or the like, C6-10 aryl, where the aryl may be substituted by halogen, C1-4 alkyl or C1-4 haloalkyl or the like, R4 is H, halogen or C1-4 alkyl. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT