3883-95-2

Basic information

• Product Name: 3-BROMO-2-HYDROXYBENZOIC ACID
• Synonyms: 3-BROMOSALICYLIC ACID;3-BROMO-2-HYDROXYBENZOIC ACID;AURORA KA-2536;Zinc02507163;Benzoic acid,3-broMo-2-hydroxy-
• CAS NO: 3883-95-2
• Molecular Formula: C₇H₅BrO₃
• Molecular Weight: 217.0168
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
• Mol File: 3883-95-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 219-220 °C
• Boiling Point: 301.4 °C at 760 mmHg
• Flash Point: 136.1 °C
• Appearance: /
• Density: 1.861 g/cm³
• Vapor Pressure: 0.000469mmHg at 25°C
• Refractive Index: 1.654
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Methanol, DMSO
• PKA: 2.43±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-2-HYDROXYBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-HYDROXYBENZOIC ACID(3883-95-2)
• EPA Substance Registry System: 3-BROMO-2-HYDROXYBENZOIC ACID(3883-95-2)

Safety Data

• Hazardous Substances Data: 3883-95-2(Hazardous Substances Data)

Usage

Uses

3-Bromo-2-hydroxybenzoic Acid is a potential an intermediate formed in the synthesis of 3-[4-(2-Pyridylsulfamoyl)phenyl] Sulfasalazine (P995810), an impurity of Sulfasalazine (S699084), an anti-inflammatory (gastrointestinal). Sulfasalazine has been used in granulomatous colitis.

InChI:InChI=1/C7H5BrO3/c8-5-3-1-2-4(6(5)9)7(10)11/h1-3,9H,(H,10,11)

Upstream product

• 56-23-5 tetrachloromethane 
• 95-56-7 2-hydroxybromobenzene 
• 50390-26-6 3-bromo-2-hydroxy-5-sulfobenzoic acid 
• 124-38-9 carbon dioxide 
• 142273-81-2 1,3-dibromo-2-(methoxymethoxy)benzene 
• 854914-90-2 3-bromo-2-hydroxy-thiobenzoic acid S-methyl ester 
• 97-05-2 5-sulfosalicylic Acid 
• 1333434-76-6 2-bromophenyl tert-butyl carbonate 
• 101083-97-0 3-amino-7-bromo-tropolone 
• 69-72-7 salicylic acid 
• 108-93-0 cyclohexanol 
• 108-94-1 cyclohexanone 
• 57688-24-1 3-bromo-2-hydroxy-5-nitro-benzoic acid 
• 831-51-6 3-amino-5-nitrosalicylic acid 

Downstream Products

• 101084-39-3 2-methoxy-3-bromobenzoic acid 
• 130883-74-8 3,3'-dibromo-5,5'-dicarboxy-4,4'-dihydroxydiphenylmethane 
• 124-38-9 carbon dioxide 
• 95-56-7 2-hydroxybromobenzene 
• 1175710-41-4 C₁₂H₈O₅ 
• 1879887-94-1 2-morpholino-8-(naphthalen-1-yl)-4H-1,3-benzoxazin-4-one 
• 267651-23-0 1-(3-bromo-2-methoxyphenyl)ethan-1-one 
• 30762-15-3 3-hexylsalicylic acid 
• 260806-90-4 methyl 3-bromo-2-methoxybenzoate 
• 885270-74-6 8-bromo-2H-chromene-3-carboxylic acid 

Relevant articles and documents

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

Despite major advances in the β-lactamase inhibitor field, certain enzymes remain refractory to inhibition by agents recently introduced. Most important among these are the class B (metallo) enzyme NDM-1 of Enterobacteriaceae and the class D (OXA) enzymes

BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF

Disclosed herein are antimicrobial compounds, compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use a therapeutic agents.

BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF

Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the method of use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents, for example, β-lactamase inhibitors (BLIs).