87142-63-0

Usage

Uses

Used in Research Chemicals:
1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one is used as a research chemical for [application reason], as it helps in understanding the effects and mechanisms of action of stimulant drugs on the brain's neurotransmitter systems.
Used in Recreational Substances:
In some cases, 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one is used as a recreational substance for [application reason], due to its stimulant and euphoric effects. However, it is important to note that its use in this context is not approved for medical use and may pose health risks due to the lack of comprehensive research on its long-term effects.

Upstream product

• 75144-12-6 1-(3,4-dichlorophenyl)-3-dimethylamino-1-propanone hydrochloride 
• 2642-63-9 3',4'-dichloroacetophenone 

Relevant academic research and scientific papers

Evaluation of some Mannich bases derived from substituted acetophenones against P-388 lymphocytic leukemia and on respiration in isolated rat liver mitochondria

Series of 3-dimethylamino-1-aryl-1-propanone hydrobromides (IV) and 3-dimethylamino-2-dimethylaminomethyl-1-aryl-1-propanone dihydrobromides (V) were synthesized. Evaluation of these derivatives against P-388 lymphocytic leukemia growth revealed that two compounds show promise as antineoplastic agents. Compounds of the V series were unstable in phosphate buffer (in contrast to series IV), and when the same nuclear substituent was present in both series of compounds, V was ~ 100 times more active than IV in both the stimulation and inhibition of respiration of mitochondria isolated from rat liver cells. Representatives from both series showed that respiration in mitochondria was affected by changing the pH of the aqueous buffer from 7.4 to 6.9 or 6.4 and by reducing the temperature from 37° to 20°. The compounds showed reactivity toward a biomimetic thiol.