87154-95-8Relevant academic research and scientific papers
Physico-chemical properties and stabilities of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinon e (OPC-8212)
Shimizu,Osumi,Niimi,Nakagawa
, p. 334 - 341 (2007/10/02)
3,4-Dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (OPC-8212), a new positive inotropic agent, was examined to clarify its physico-chemical properties, i.e. elemental analysis, melting point, spectra (UV, IR, NMR, MS), X-ray diffraction pattern, thermal analysis, solubilities, pKa, partition coefficient and chromatography (HPLC, TLC). Some degradation products of OPC-8212 were identified in acidic and basic solutions. OPC-8212 was determined by nonaqueous titration.
