81840-22-4

Upstream product

• 3279-90-1 6-bromo-3,4-dihydro-1H-quinolin-2-one 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 201230-82-2 carbon monoxide 
• 87154-95-8 6-(1-piperazinyl)-3,4-dihydro-2(1H)-quinolinone 
• 43204-63-3 bis(2-bromoethyl)amine hydrobromide 
• 22246-13-5 6-amino-3,4-dihydro-1H-quinolin-2-one 
• 100-07-2 4-methoxy-benzoyl chloride 
• 86813-31-2 6-(1-piperazinyl)-3,4-dihydrocarbostyril hydrobromide 

Relevant academic research and scientific papers

Concise Synthesis of Vesnarinone and Its Analogues by Using Pd-Catalyzed C-N Bond-Forming Reactions

An efficient and concise synthesis of vesnarinone and its analogues from readily available starting materials and by using catalytic C-N bond-forming reactions is reported. In this protocol, a homogeneous Pd-catalyzed Buchwald-Hartwig amination and a supported Pd nanoparticles catalyzed aminocarbonylation were utilized as the two key reactions to prepare vesnarinone in an overall yield of 73 %. Sixteen analogues were also synthesized in up to 89 % overall yield. An efficient and concise synthesis of vesnarinone was achieved in three steps by using palladium-catalyzed C-N bond-forming reactions, which included the Buchwald-Hartwig amination and an aminocarbonylation reaction. High overall yields were obtained by using this strategy for the preparation of several vesnarinone analogues.