871583-24-3Relevant academic research and scientific papers
Amide-Directed C?H Sodiation by a Sodium Hydride/Iodide Composite
Huang, Yinhua,Chan, Guo Hao,Chiba, Shunsuke
supporting information, p. 6544 - 6547 (2017/05/29)
A new protocol for amide-directed ortho and lateral C?H sodiation is enabled by sodium hydride (NaH) in the presence of either sodium iodide (NaI) or lithium iodide (LiI). The transient organosodium intermediates could be transformed into functionalized aromatic compounds.
Discovery of potent and selective DP1 receptor antagonists in the azaindole series
Leblanc, Yves,Roy, Patrick,Dufresne, Claude,Lachance, Nicolas,Wang, Zhaoyin,O'Neill, Gary,Greig, Gillian,Denis, Danielle,Mathieu, Marie-Claude,Slipetz, Deborah,Sawyer, Nicole,Tsou, Nancy
body text, p. 2125 - 2128 (2009/12/03)
Azaindole based structures were evaluated as DP1 receptor antagonists. This work has lead to the discovery of potent, selective and distinct DP1 receptor antagonists.
The Hemetsberger-Knittel synthesis of substituted 5-, 6-, and 7-azaindoles
Roy, Patrick J.,Dufresne, Claude,Lachance, Nicolas,Leclerc, Jean-Philippe,Boisvert, Michel,Wang, Zhaoyin,Leblanc, Yves
, p. 2751 - 2757 (2007/10/03)
A series of substituted 5-, 6-, and 7-azaindoles were prepared via the Hemetsberger-Knittel reaction. In general, better yields were obtained at higher temperatures and shorter reaction times than required for the formation of the analogous indoles, and in some cases, only decomposition occurred below a minimum temperature. The resulting templates offer up to five sites for subsequent functionalization to allow a wide range of chemical diversity. Georg Thieme Verlag Stuttgart.
