194151-94-5Relevant academic research and scientific papers
PYRIDAZINONES AND METHODS OF USE THEREOF
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Page/Page column 263; 264, (2019/04/11)
Disclosed are compounds according to Formula (A), and related tautomers and pharmaceutical compositions. Also disclosed are therapeutic methods, e.g., of treating kidney diseases, using the compounds of Formula (A).
Discovery of potent and selective DP1 receptor antagonists in the azaindole series
Leblanc, Yves,Roy, Patrick,Dufresne, Claude,Lachance, Nicolas,Wang, Zhaoyin,O'Neill, Gary,Greig, Gillian,Denis, Danielle,Mathieu, Marie-Claude,Slipetz, Deborah,Sawyer, Nicole,Tsou, Nancy
body text, p. 2125 - 2128 (2009/12/03)
Azaindole based structures were evaluated as DP1 receptor antagonists. This work has lead to the discovery of potent, selective and distinct DP1 receptor antagonists.
The Hemetsberger-Knittel synthesis of substituted 5-, 6-, and 7-azaindoles
Roy, Patrick J.,Dufresne, Claude,Lachance, Nicolas,Leclerc, Jean-Philippe,Boisvert, Michel,Wang, Zhaoyin,Leblanc, Yves
, p. 2751 - 2757 (2007/10/03)
A series of substituted 5-, 6-, and 7-azaindoles were prepared via the Hemetsberger-Knittel reaction. In general, better yields were obtained at higher temperatures and shorter reaction times than required for the formation of the analogous indoles, and in some cases, only decomposition occurred below a minimum temperature. The resulting templates offer up to five sites for subsequent functionalization to allow a wide range of chemical diversity. Georg Thieme Verlag Stuttgart.
TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS
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, (2008/06/13)
This invention relates to certain novel benzoxazinone compounds and derivatives thereof, their synthesis, and their use as oxytocin receptor antagonists. One application of these compounds is in the treatment of preterm labor. The ability of the compounds to relax uterine contractions in mammals also makes them useful for treating dysmenorrhea and stopping labor prior to cesarean delivery. A typical compound is as follows: STR1
