87164-98-5Relevant academic research and scientific papers
Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides
Demjén, András,Alf?ldi, Róbert,Angyal, Anikó,Gyuris, Márió,Hackler, László,Szebeni, Gábor J.,W?lfling, János,Puskás, László G.,Kanizsai, Iván
, (2018/07/13)
The synthesis and in vitro cytotoxic characteristics of new imidazo[1,2-b]pyrazole-7-carboxamides were investigated. Following a hit-to-lead optimization exploiting 2D and 3D cultures of MCF-7 human breast, 4T1 mammary gland, and HL-60 human promyelocytic leukemia cancer cell lines, a 67-membered library was constructed and the structure–activity relationship (SAR) was determined. Seven synthesized analogues exhibited sub-micromolar activities, from which compound 63 exerted the most significant potency with a remarkable HL-60 sensitivity (IC50 = 0.183 μM).
Reaction of enamines and azaenamines containing a thioamide group with dimethyl acetylenedicarboxylate
Belskaya,Lugovik,Ivina,Bakulev,Fan
, p. 888 - 900 (2014/10/16)
The reaction between enamines and azaenamines containing a thioamide group and dimethyl acetylenedicarboxylate was studied under various conditions. It was shown that exchanging one of the carbon atoms in the structure of the investigated compounds for a nitrogen atom significantly affected the reactivity. Functionalized thiopyrans and thiazolidinones were obtained during this investigation.
Reaction of enamines and azaenamines containing a thioamide group with dimethyl acetylenedicarboxylate
Belskaya,Lugovik,Ivina,Bakulev,Fan
, p. 888 - 900 (2015/09/28)
The reaction between enamines and azaenamines containing a thioamide group and dimethyl acetylenedicarboxylate was studied under various conditions. It was shown that exchanging one of the carbon atoms in the structure of the investigated compounds for a nitrogen atom significantly affected the reactivity. Functionalized thiopyrans and thiazolidinones were obtained during this investigation.
ACETALS OF LACTAMS AND AMIDES. 42. REACTIONS OF ENAMINO AMIDES AND ENAMINO ESTERS WITH SOME FORMYLATING AGENTS. SYNTHESIS OF DERIVATIVES OF 2-PYRIDONE AND OF PYRIMIDIN-4- AND -6-ONES
Granik, V. G.,Ershov, L. V.,Grizik, S. I.,Chistyakov, V. V.
, p. 1026 - 1031 (2007/10/02)
The reactions of enamino esters and enamino amides with the diethyl acetal of dimethylformamide and with orthoformic ester have been investigated and it has been shown that the process takes place in two directions - with the formation of pyrimidone or 2-
