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• 917-92-0 3,3-Dimethylbut-1-yne 
• 622-79-7 benzyl azide 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Mononuclear Copper Complexes with Tridentate Tris(N-heterocyclic carbene): Synthesis and Catalysis of Alkyne-Azide Cycloaddition

Mononuclear copper complexes modified with tridentate tris(N-heterocyclic carbene) (triscarbene) ligands are synthesized. The structures of the copper-triscarbene complexes are characterized using X-ray crystallography, X-ray absorption near edge structur

Base-Free Copper-Catalyzed Azide-Alkyne Click Cycloadditions (CuAAc) in Natural Deep Eutectic Solvents as Green and Catalytic Reaction Media**

The click cycloaddition of azides to alkynes affording 1,2,3-triazoles is a widely used and effective chemical transformation, applied to obtain relevant products in medicine, biology, and materials science. In this work, a set of natural deep eutectic so

Cu-tetracatechol metallopolymer catalyst for three component click reactions and β-borylation of α,β-unsaturated carbonyl compounds

Phenol-metal coordination polymers are used in applications such as catalysis, sensing and separation science. In addition, combining eco-friendly conditions with economical and handling advantages of the polymeric catalyst is of interest to the community

Side-Arm Functionalized Silylene Copper(I) Complexes in Catalysis

A convenient new method was added to the toolbox of the ligand design of N-heterocyclic silylenes and their transition-metal complexes. Herein we report on six novel compounds of two novel classes of copper(I) complexes based on the benzamidinate silylene

A dicopper(i)-dimesoionic carbene complex as a click catalyst: Mechanistic implications

A dicopper(i) complex comprising a dimesoionic carbene and an acetate-bridge is synthesized and fully characterized. This complex is a potent pre-catalyst for the azide-alkyne cycloaddition reaction. A full kinetic investigation shows a first order in azi

An Organometallic Cu20 Nanocluster: Synthesis, Characterization, Immobilization on Silica, and "click" Chemistry

The development of atomically precise nanoclusters (APNCs) protected by organometallic ligands, such as acetylides and hydrides, is an emerging area of nanoscience. In principle, these organometallic APNCs should not require harsh pretreatment for activat

Hydrosoluble Cu(i)-DAPTA complexes: Synthesis, characterization, luminescence thermochromism and catalytic activity for microwave-assisted three-component azide-alkyne cycloaddition click reaction

New hydrosoluble and air-stable Cu(i) halide compounds, viz. [CuX(DAPTA)3] (1) and (2), and [Cu(μ-X)(DAPTA)2]2 (3) and (4) (X = Br or I, in this order), have been prepared by reacting Cu(i) halide (i.e., bromide or iodide)

Copper complexes bearing C-scorpionate ligands: Synthesis, characterization and catalytic activity for azide-alkyne cycloaddition in aqueous medium

Reactions of CuX (X = Br or I) and [Cu(MeCN)4][BF4] with the neutral C-scorpionates HC(3,5-Me2pz)3 and HC(3-Phpz)3 (Tpm? and TpmPh, respectively) proceed readily at room temperat

Eight-membered-ring diaminocarbenes bearing naphthalene moiety in the backbone: DFT studies, synthesis of amidinium salts, generation of free carbene, metal complexes, and solvent-free copper catalyzed azide-alkyne cycloaddition (CuAAC) reaction

A new type of eight-membered ring N-heterocyclic carbene (NHC) bearing a rigid naphthalene moiety in the backbone is reported for the first time. Stereoelectronic properties of 4,5-dihydro-1H-naphtho[1,8-ef][1,3]diazocin-3(2H)-ylidene (NaphtDHD) and small

Synthesis of mono- and binuclear Cu(II) complexes bearing unsymmetrical bipyridine-pyrazole-amine ligand and their applications in azide-alkyne cycloaddition

Mono- and binuclear Cu(II) complexes bearing an unsymmetrical bipyridine-pyrazole-amine ligand were synthesized and characterized using X-ray diffraction. The mononuclear complex could be converted to the corresponding binuclear complexes under basic conditions due to the lability of the pyrazolyl N-H. Both complexes proved to be effective catalysts for azide-alkyne cycloaddition to form triazoles, with the binuclear complex exhibiting higher catalytic activity than the corresponding mononuclear one. The binuclear complex was effective at catalyst loadings as low as 0.0125 mol %, making it one of the most active catalysts for this reaction to date. Therefore, this catalyst was applied in the synthesis of potentially biologically active molecules. At 0.1-0.3 mol % catalyst loading, three precursors of Sorafenib analogs were synthesized in excellent yields. A one-pot variant of the reaction, generating the azide in situ, could also be performed using the binuclear complex as the catalyst. The transition metal complex bearing an unsymmetrical ligand may exhibit excellent catalytic activity, which represents a direction for developing new highly active catalysts.