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3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione is a chemical compound with a complex structure that features a cyclopropyl group, a fluoro-iodophenyl moiety, and a methylamino substituent. 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione is characterized by its potential reactivity and functional groups that can be utilized in various chemical reactions and applications.

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  • 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)-pyrimidine-2,4(1H,3H)-dione

    Cas No: 871700-22-0

  • USD $ 1.2-5.0 / Kiloliter

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  • 871700-22-0 Structure
  • Basic information

    1. Product Name: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione
    2. Synonyms: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione;3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione
    3. CAS NO:871700-22-0
    4. Molecular Formula: C14H13FIN3O2
    5. Molecular Weight: 401.1747932
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 871700-22-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 459.4±55.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.85±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C(protect from light)
    8. Solubility: N/A
    9. PKA: 3.83±0.20(Predicted)
    10. CAS DataBase Reference: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione(CAS DataBase Reference)
    11. NIST Chemistry Reference: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione(871700-22-0)
    12. EPA Substance Registry System: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione(871700-22-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 871700-22-0(Hazardous Substances Data)

871700-22-0 Usage

Uses

Used in Pharmaceutical Industry:
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione is used as a reagent for the preparation of 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-d]pyrimidine derivatives and related compounds. These derivatives are of significant interest due to their potential therapeutic applications in the treatment of cancer and rheumatic diseases.
In the development of pharmaceuticals, 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione serves as a key intermediate in the synthesis of various drug candidates. Its unique structural features allow for the creation of molecules that can target specific biological pathways and receptors, offering new avenues for the treatment of challenging medical conditions such as cancer and rheumatic diseases.
The use of 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione in the pharmaceutical industry highlights the importance of chemical diversity and innovation in drug discovery. By leveraging the properties of 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione, researchers can design and synthesize new molecules with improved efficacy, selectivity, and safety profiles, ultimately contributing to the advancement of medicine and healthcare.

Check Digit Verification of cas no

The CAS Registry Mumber 871700-22-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,1,7,0 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 871700-22:
(8*8)+(7*7)+(6*1)+(5*7)+(4*0)+(3*0)+(2*2)+(1*2)=160
160 % 10 = 0
So 871700-22-0 is a valid CAS Registry Number.

871700-22-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)-2,4(1H,3H )-pyrimidinedione

1.2 Other means of identification

Product number -
Other names 3-cyclopropyl-[1,2,4]thiadiazol-5-ylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:871700-22-0 SDS

871700-22-0Relevant articles and documents

Method for synthesizing key intermediate of trametinib

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Paragraph 0029, (2019/02/27)

The invention discloses a method for synthesizing a key intermediate of trametinib, malonic acid monomethyl amide monoethyl ester and isosuccinic acid have a ring-closure reaction to obtain a crude product of a pyridine triketone compound; the obtained cr

5-AMINO-2,4,7-TRIOXO-3,4,7,8-TETRAHYDRO-2H-PYRIDO’2,3-D! PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF CANCER

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Page/Page column 152, (2008/06/13)

The present invention relates to a pyrimidine compound represented by the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a pharmaceutical agent for the prophylaxis or treatment of a disease caused by undesirable cell proliferation, particularly an antitumor agent, which contains such compound. The compound of the present invention has superior undesirable cell proliferation suppressing action, particularly, an antitumor action, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, antirheumatoid agent and the like. In addition, by the combined use with other antitumor agent such as alkylating agent, metabolism antagonist and the like, it can be a more effective antitumor agent.

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