871716-67-5Relevant articles and documents
PROTEIN SECRETION INHIBITORS
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Paragraph 00205, (2022/03/09)
Provided herein are secretion inhibitors, such as inhibitors of Sec61 for example of Formula (I), methods for their preparation, related pharmaceutical compositions, and method for using the same.
2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors
Dai, Chaoyang,Li, Dansu,Popovici-Muller, Janeta,Zhao, Lianyun,Girijavallabhan, Vinay M.,Rosner, Kristin E.,Lavey, Brian J.,Rizvi, Razia,Shankar, Bandarpalle B.,Wong, Michael K.C.,Guo, Zhuyan,Orth, Peter,Strickland, Corey O.,Sun, Jing,Niu, Xiaoda,Chen, Shiying,Kozlowski, Joseph A.,Lundell, Daniel J.,Piwinski, John J.,Shih, Neng-Yang,Siddiqui, M. Arshad
scheme or table, p. 3172 - 3176 (2011/06/24)
TNF-α converting enzyme (TACE) inhibitors are promising agents to treat inflammatory disorders and cancer. We have investigated novel tartrate diamide TACE inhibitors where the tartrate core binds to zinc in a unique tridentate fashion. Incorporating (R)-