871717-03-2

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-(3-bromophenyl)-, 1,1-dimethylethyl ester
• CAS NO: 871717-03-2
• Molecular Formula: C15H20BrNO2
• Molecular Weight: 326.233
• Mol File: 871717-03-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-(3-bromophenyl)-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-(3-bromophenyl)-, 1,1-dimethylethyl ester(871717-03-2)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-(3-bromophenyl)-, 1,1-dimethylethyl ester(871717-03-2)

Safety Data

• Hazardous Substances Data: 871717-03-2(Hazardous Substances Data)

Usage

Role in pharmaceutical research

Building block for drug synthesis It is used as an intermediate compound in the synthesis of various drugs and bioactive molecules.

Potential therapeutic applications

Treatment of neurological disorders and cancer The compound has been studied for its potential role in treating these medical conditions.

Use as a reagent

Organic synthesis and chemical research It serves as a reagent in laboratory settings for organic synthesis and other chemical reactions.

Tert-butyl ester derivative

3-bromopyroglutamic acid This compound is derived from 3-bromopyroglutamic acid and has a tert-butyl ester group.

Stability and ease of handling

Laboratory settings The compound is known for its stability and ease of handling in laboratory environments.

Handling precautions

Potential hazards This chemical may pose hazards if not properly managed, so it is important to handle it with care.

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1171898-22-8 2-(3-bromophenyl)pyrrolidine HCl 
• 374589-00-1 5-(3-bromophenyl)-3,4-dihydro-2H-pyrrole 
• 108-36-1 1,3-dibromobenzene 
• 383127-79-5 (+/-) 2-(3-bromophenyl)pyrrolidine 

Downstream Products

• 1171897-02-1 tert-butyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyrrolidine-1-carboxylate 

Relevant articles and documents

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

Pyrrolopyrimidines and Pyrrolopyridines

Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.