87174-85-4Relevant academic research and scientific papers
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: Effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity
Rosowsky, Andre,Forsch, Ronald,Uren, Jack,Wick, Michael,Kumar, A. Ashok,Freisheim, James H.
, p. 1719 - 1724 (2007/10/02)
Chain-extended analogues of methotrexate were synthesized by condensation of 4-amino-4-deoxy-N10-methylpteroic acid with esters of L-α-aminoadipic, L-α-aminopimelic, and L-α-aminosuberic acids, followed by ester hydrolysis with acid or base. Co
