26630-55-7Relevant academic research and scientific papers
Practical and efficient enantioselective synthesis of α-amino acids in aqueous media
Suarez, Rosa M.,Sestelo, Jose Perez,Sarandeses, Luis A.
, p. 3584 - 3587 (2007/10/03)
Enantiomerically pure natural and unnatural α-amino acids have been synthesized from a chiral melhyleneoxazolidinone by means of a highly diastereoselective 1,4-conjugate addition of alkyl iodides in aqueous media. The zinc-copper conjugate addition reaction exhibits high chemoselectivity, with the possibility of using functionalized iodides, to afford a single diastereomer in short reaction times and with good yields.
Peptides of 2-aminopimelic acid: Antibacterial agents that inhibit diaminopimelic acid biosynthesis
Berges,DeWolf Jr.,Dunn,Grappel,Newman,Taggart,Gilvarg
, p. 89 - 95 (2007/10/02)
Succinyl-CoA:tetrahydrodipicolinate-N-succinyltransferase is a key enzyme in the biosynthesis of diaminopimelic acid (DAP), a component of the cell wall peptidoglycan of nearly all bacteria. This enzyme converts the cyclic precursor tetrahydrodipicolinic
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: Effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity
Rosowsky, Andre,Forsch, Ronald,Uren, Jack,Wick, Michael,Kumar, A. Ashok,Freisheim, James H.
, p. 1719 - 1724 (2007/10/02)
Chain-extended analogues of methotrexate were synthesized by condensation of 4-amino-4-deoxy-N10-methylpteroic acid with esters of L-α-aminoadipic, L-α-aminopimelic, and L-α-aminosuberic acids, followed by ester hydrolysis with acid or base. Co
