871817-19-5

Basic information

• Product Name: 2-(3-chloro-4-fluoro-phenyl)-[1,3,2]dioxaborolane
• CAS NO: 871817-19-5
• Molecular Weight: 200.405
• Mol File: 871817-19-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(3-chloro-4-fluoro-phenyl)-[1,3,2]dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chloro-4-fluoro-phenyl)-[1,3,2]dioxaborolane(871817-19-5)
• EPA Substance Registry System: 2-(3-chloro-4-fluoro-phenyl)-[1,3,2]dioxaborolane(871817-19-5)

Safety Data

• Hazardous Substances Data: 871817-19-5(Hazardous Substances Data)

Upstream product

• 107-21-1 ethylene glycol 
• 144432-85-9 3-chloro-4-fluorophenylboronic acid 

Relevant articles and documents

Identification of borinic esters as inhibitors of bacterial cell growth and bacterial methyltransferases, CcrM and MenH

As bacteria continue to develop resistance toward current antibiotics, we find ourselves in a continual battle to identify new antibacterial agents and targets. We report herein a class of boron-containing compounds termed borinic esters that have broad spectrum antibacterial activity with minimum inhibitory concentrations (MIC) in the low microgram/mL range. These compounds were identified by screening for inhibitors against Caulobacter crescentus CcrM, an essential DNA methyltransferase from Gram negative α-proteobacteria. In addition, we demonstrate that borinic esters inhibit menaquinone methyltransferase in Gram positive bacteria using a new biochemical assay for MenH from Bacillus subtilis. Our data demonstrate the potential for further development of borinic esters as antibacterial agents as well as leads to explore more specific inhibitors against two essential bacterial enzymes.