871834-72-9

Upstream product

• 871834-64-9 (S)-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoxaline 
• 871834-70-7 5-((3,5-bis(trifluoromethyl)phenyl)chloromethyl)-2-methyl-2H-tetrazole 
• 85068-32-2 3,5-bis(trifluoromethyl)phenylacetonitrile 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 769132-64-1 (3,5-bis-trifluoromethylphenyl)-bromo-acetonitrile 
• 18107-18-1 diazomethyl-trimethyl-silane 

Relevant academic research and scientific papers

Tetrazole and ester substituted tetrahydoquinoxalines as potent cholesteryl ester transfer protein inhibitors

Cholesteryl ester transfer protein is a plasma glycoprotein that transfers cholesterol ester between lipoprotein particles. Inhibition of this protein, in vitro and in vivo, produces an increase in plasma high density lipoprotein cholesterol (HDL-C). This

Inhibitors of cholesteryl ester transfer protein

This invention relates to inhibitors of CETP and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders mediated by CETP.