87187-81-3Relevant academic research and scientific papers
Design, synthesis, biological and in silico evaluation of phenylene (bis) hydrazone derivatives against osteosarcoma cancer
Govindaiah, Pilli,Kumar, Rakesh,Guttula, Praveen Kumar,Gupta, Mukesh Kumar,Jaya Prakash
, p. 2638 - 2645 (2021/01/05)
Three sets of differentphenylene-bis(hydrazone) derivatives namely,Gc, Gd and Ge,were designed, synthesized and evaluated for their molecular properties andin vitro anticancer activity against human osteosarcoma MG-63 cells. All compounds showed potent an
Use of acylhydrazine- and acylhydrazone-type ligands to promote CuI-catalyzed C-N cross-coupling reactions of aryl bromides with N-heterocycles
Li, Liuyi,Zhu, Lei,Chen, Dagui,Hu, Xuelei,Wang, Ruihu
supporting information; experimental part, p. 2692 - 2696 (2011/06/25)
A series of ten acylhydrazine- and acylhydrazone-type ligands were designed and synthesized. Their electronic and steric properties were easily modified and tuned by varying the substituents in the vicinity of the acylhydrazine and acylhydrazone units. The effect of ligands on the catalytic activity of Ullmann reactions was assessed by using a combination of these ligands with CuI. The catalytic system is very efficient for the C-N coupling reaction of azoles with aryl and heteroaryl bromides. A simple and efficient procedure for copper-catalyzed C-N cross-coupling reactions between aryl bromides and NH-containingheterocycles is illustrated. Readily available acylhydrazine- and acylhydrazone-typeligands promote the reaction.
