871875-68-2Relevant academic research and scientific papers
Dialkylation of indoles with trichloroacetimidates to access 3,3-disubstituted indolenines
Suzuki, Tamie,Mate, Nilamber A.,Adhikari, Arijit A.,Chisholm, John D.
, (2019)
2-Substituted indoles may be directly transformed to 3,3-dialkyl indolenines with trichloroacetimidate electrophiles and the Lewis acid TMSOTf. These reactions provide rapid access to complex indolenines which are present in a variety of complex natural products and medicinally relevant small molecule structures. This method provides an alternative to the use of transition metal catalysis. The indolenines are readily transformed into spiroindoline systems which are privileged scaffolds in medicinal chemistry.
Palladium-catalyzed decarboxylative allylation and benzylation of N-alloc and N-Cbz indoles
Montgomery, Thomas D.,Zhu, Ye,Kagawa, Natsuko,Rawal, Viresh H.
, p. 1140 - 1143 (2013/03/29)
A set of general methods for the palladium-catalyzed decarboxylative C3-allylation and C3-benzylation of indoles, starting from the corresponding N-alloc and N-Cbz indoles, respectively, is reported. This chemistry provides ready access to a wide range of
