87190-79-2

Basic information

• Product Name: 3'-azido-2',3'-dideoxy-5-methylcytidine
• Synonyms: 3'-azido-2',3'-dideoxy-5-methylcytidine;3'-Azido-2',3'-dideoxy-4-deoxo-4-imino-5-methyluridine;CS-92;AzddMeC
• CAS NO: 87190-79-2
• Molecular Formula: C10H14N6O3
• Molecular Weight: 266.25656
• Mol File: 87190-79-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 3'-azido-2',3'-dideoxy-5-methylcytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-azido-2',3'-dideoxy-5-methylcytidine(87190-79-2)
• EPA Substance Registry System: 3'-azido-2',3'-dideoxy-5-methylcytidine(87190-79-2)

Safety Data

• Hazardous Substances Data: 87190-79-2(Hazardous Substances Data)

Usage

Uses

AzddMeC is used as an antiviral agent for treating viral infection.

Upstream product

• 66323-42-0 1-(5′-O-acetyl-3′-azido-2′,3′-dideoxy-β-D-ribofuranosyl)thymine 
• 29706-84-1 1-(3-azido-2,3-deoxy-5-O-trityl-β-D-erythro-pentofuranosyl)thymine 
• 87190-77-0 1-(5-O-Acetyl-3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-methyl-4-(1,2,4-triazol-1-yl)-2(1H)-pyrimidinone 

Downstream Products

• 87190-81-6 3'-amino-2',3'-dideoxy-5-methylcytidine 

Relevant articles and documents

3'-Substituted 2',3'-Dideoxynucleoside Analogues as Potential Anti-HIV (HTLV-III/LAV) Agents

A series of 2',3'-unsaturated and 3'-substituted 2',3'-dideoxynucleoside analogues of purines and pyrimidines have been synthesized and evaluated for their inhibitory activity against human immunodeficiency virus (HIV).The 2',3'-unsaturated analogues of 2',3'-dideoxycytidine (ddeCyd) and 2',3'-dideoxythymidine (ddeThd), 3'-azido-2',3'-dideoxythymidine (AzddThd), 3'-fluoro-2',3'-dideoxythymidine, 2',3'-dideoxycytidine (ddCyd), and 2',3'-dideoxyadenosine (ddAdo) emerged as the most potent inhibitors of HIV-induced cytopathogenicity in the human T lymphocyte cell lines ATH8 and MT4.In ATH8 cells ddCyd, ddeCyd, and ddAdo had the highest therapeutic index whereas in MT4 cells AzddThd, ddThd, ddCyd, and ddAdo were the most selective.Derivatives from ddThd in which the substituent group was linked to the 3'-carbon atom via a thio, sulfonyl, or oxygen bridge were far less inhibitory to HIV than was AzddThd.