871905-75-8

Upstream product

• 645-45-4 hydrocinnamic acid chloride 
• 178059-33-1 (5R,6R)-5-Benzyl-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 76513-69-4 (2-trimethylethylsilylethoxy)methyl chloride 
• 178059-32-0 (1R,2R)-1-Benzyl-3-(N-benzyl-hydrazino)-2-(2-trimethylsilanyl-ethoxymethoxy)-propylamine 
• 173261-25-1 (5R,6R)-1,5-Dibenzyl-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 178059-31-9 N'-Benzyl-N'-((2R,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyl)-hydrazinecarboxylic acid benzyl ester 
• 173261-24-0 N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester 

Downstream Products

• 871905-30-5 (5R,6R)-5-Benzyl-2,4-bis-(4-hydroxy-benzyl)-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-63-4 (5R,6R)-2,5-Dibenzyl-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-64-5 (5R,6R)-5-Benzyl-2-(1H-indazol-5-ylmethyl)-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-33-8 3-[5-benzyl-2-(1H-indazol-5-ylmethyl)-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine 
• 871905-36-1 (5R,6R)-2-(3-Amino-1H-indazol-5-ylmethyl)-4,5-dibenzyl-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-34-9 (5R,6R)-4-(3-Amino-benzyl)-5-benzyl-2-(1H-indazol-5-ylmethyl)-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-32-7 3-[(5R,6R)-2,5-Dibenzyl-3-oxo-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-4-ylmethyl]-N-hydroxy-benzamidine 
• 871905-35-0 (5R,6R)-4,5-Dibenzyl-2-(1H-indazol-5-ylmethyl)-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-17-8 (5R,6R)-5-Benzyl-2,4-bis-(4-hydroxy-3-methoxy-benzyl)-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-31-6 (5R,6R)-2,4-Bis-(4-amino-3-methoxy-benzyl)-5-benzyl-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 
• 871905-65-6 (5R,6R)-2-(3-Amino-1H-indazol-5-ylmethyl)-5-benzyl-1-(3-phenyl-propionyl)-6-(2-trimethylsilanyl-ethoxymethoxy)-[1,2,4]triazepan-3-one 

Relevant academic research and scientific papers

Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains

As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic urea (I) was undertaken by incorporating acyl groups as P 1′ ligands. The extensive SA