173261-24-0Relevant academic research and scientific papers
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains
Zhao, Chen,Sham, Hing L.,Sun, Minghua,Stoll, Vincent S.,Stewart, Kent D.,Lin, Shuqun,Mo, Hongmei,Vasavanonda, Sudthida,Saldivar, Ayda,Park, Chang,McDonald, Edith J.,Marsh, Kennan C.,Klein, Larry L.,Kempf, Dale J.,Norbeck, Daniel W.
, p. 5499 - 5503 (2007/10/03)
As part of our efforts to identify potent HIV-1 protease inhibitors that are active against resistant viral strains, structural modification of the azacyclic urea (I) was undertaken by incorporating acyl groups as P 1′ ligands. The extensive SA
A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease.
Sham, Hing L.,Zhao, Chen,Stewart, Kent D.,Betebenner, David A.,Lin, Shuqun,et al.
, p. 392 - 397 (2007/10/03)
The design, synthesis, and molecular modeling studies of a novel series of azacyclic ureas, which are inhibitors of human immunodeficiency virus type 1 (HIV-1) protease that incorporate different ligands for the S1', S2, and S2' substrate-binding sites of
