872-06-0Relevant articles and documents
Method of manufacturing sulfonylhalides unsatd. alkyl
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Paragraph 0041; 0042; 0043, (2017/03/08)
PROBLEM TO BE SOLVED: To provide a production method capable of industrially simply and efficiently providing unsaturated alkyl halides useful as functional compounds, pharmaceuticals, agrochemicals or intermediates thereof.SOLUTION: Vinyl chloride and a Grignard reagent derived from a dihaloalkane represented by the specified general formula (1), where Xand Xeach independently represent Cl, Br or I and n represents an integer from 4 to 12, are reacted in the presence of an iron compound to produce unsaturated alkyl halides represented by the specified general formula (2), where Xrepresents Cl, Br or I and n represents an integer from 4 to 12.
Copper-Catalyzed Cross-Coupling Reaction of Allyl Boron Ester with 1°/2°/3°-Halogenated Alkanes
Wang, Guang-Zu,Jiang, Jian,Bu, Xiao-Song,Dai, Jian-Jun,Xu, Jun,Fu, Yao,Xu, Hua-Jian
supporting information, p. 3682 - 3685 (2015/08/18)
The cross-coupling reaction of allyl boron ester with 1°/2°/3°-halogenated alkanes in the presence of copper has been developed for the first time, which provides a mild and efficient method for the construction of saturated C(sp3)-C(sp3) bonds. This protocol shows excellent compatibility with the nonactivated primary, secondary, and even tertiary halogenated alkanes under mild conditions.
Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells
Kennedy, Andrew J.,Mathews, Thomas P.,Kharel, Yugesh,Field, Saundra D.,Moyer, Morgan L.,East, James E.,Houck, Joseph D.,Lynch, Kevin R.,MacDonald, Timothy L.
supporting information; experimental part, p. 3524 - 3548 (2011/07/07)
Sphingosine 1-phosphate (S1P) is a bioactive lipid that has been identified as an accelerant of cancer progression. The sphingosine kinases (SphKs) are the sole producers of S1P, and thus, SphK inhibitors may prove effective in cancer mitigation and chemosensitization. Of the two SphKs, SphK1 overexpression has been observed in a myriad of cancer cell lines and tissues and has been recognized as the presumptive target over that of the poorly characterized SphK2. Herein, we present the design and synthesis of amidine-based nanomolar SphK1 subtype-selective inhibitors. A homology model of SphK1, trained with this library of amidine inhibitors, was then used to predict the activity of additional, more potent, inhibitors. Lastly, select amidine inhibitors were validated in human leukemia U937 cells, where they significantly reduced endogenous S1P levels at nanomolar concentrations.
Biologically active compounds by catalytic olefin metathesis
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, (2008/06/13)
Biologically active compounds such as pheromones and precursors thereof are produced by catalyzed cross metathesis of dissimilar terminal olefins or of a cyclodiene and a terminal olefin.