872045-91-5Relevant academic research and scientific papers
NEW PHYSICAL FORM OF N,N′- DISUBSTITUTED OXABISPIDINES
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Page/Page column 35-36, (2010/11/25)
There is provided a crystalline material consisting essentially of a compound of formula I, wherein R1 to R4, A, B and D have meanings given in the description, which crystalline material is characterised in that is has surface area
PROCESS FOR THE PREPARATION OF N,N′- DISUBSTITUTED OXABISPIDINES
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Page/Page column 56-59, (2010/11/25)
There is provided a process for the preparation of a sulfonic acid salt of formula I, or a solvate thereof, which process comprises hydrogenating a sulfonic acid salt of formula II,. or a solvate thereof; in the presence of a solvent system consisting essentially of water, a C3-5 secondary alkyl alcohol and no more than 15% v/v of another organic solvent, wherein the sulfonic acid salt of formula I is optionally, without isolation, converted to a compound of formula IX, or a pharmaceutically-acceptable derivative thereof, wherein R1, R2, R3, R6, R7, R8, A, B and D have meanings given in the description.
