872045-88-0

Upstream product

• 405-04-9 3-fluoro-4-hydroxybenzonitrile 
• 106-93-4 ethylene dibromide 
• 2357-52-0 3-fluoro-4-methoxyphenyl bromide 
• 331-62-4 3-fluoro-4-methoxybenzonitrile 

Downstream Products

• 872045-91-5 AZD₁₃₀₅ 
• 1384869-53-7 4-(2-bromoethoxy)-3-fluorobenzoic acid 
• 1384869-54-8 4-(2-bromoethoxy)-3-fluorobenzoyl chloride 
• 1384869-55-9 (4-(2-bromoethoxy)-3-fluorophenyl)(4-methoxyphenyl)methanone 
• 1384869-56-0 (4-(2-bromoethoxy)-3-fluorophenyl)(4-hydroxyphenyl)methanone 

Relevant academic research and scientific papers

NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS

The invention provides novel ethylene derivatives represented by Formula I, which may be used as selective estrogen receptor modulators (SERMs) and useful in the prophylaxis and/or treatment of estrogen-dependent conditions or conditions.

New oxabispidine compounds for the treatment of cardiac arrhythmias

There is provided compounds of formula I, wherein R1, R2, R3, R41 to R46, X, Y and Z have meanings given in the description, which compounds are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

PROCESS FOR THE PREPARATION OF N,N′- DISUBSTITUTED OXABISPIDINES

There is provided a process for the preparation of a sulfonic acid salt of formula I, or a solvate thereof, which process comprises hydrogenating a sulfonic acid salt of formula II,. or a solvate thereof; in the presence of a solvent system consisting essentially of water, a C3-5 secondary alkyl alcohol and no more than 15% v/v of another organic solvent, wherein the sulfonic acid salt of formula I is optionally, without isolation, converted to a compound of formula IX, or a pharmaceutically-acceptable derivative thereof, wherein R1, R2, R3, R6, R7, R8, A, B and D have meanings given in the description.

NOVEL OXABISPIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CARDIAC ARRHYTHMIAS

There is provided compounds of formula (I), wherein R1, R2, R3, R4, R 41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.