872057-69-7

Basic information

• Product Name: C₂₁H₂₄N₄O₂S
• CAS NO: 872057-69-7
• Molecular Weight: 396.513
• Mol File: 872057-69-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₄N₄O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₄N₄O₂S(872057-69-7)
• EPA Substance Registry System: C₂₁H₂₄N₄O₂S(872057-69-7)

Safety Data

• Hazardous Substances Data: 872057-69-7(Hazardous Substances Data)

Upstream product

• 92-54-6 4-phenyl-1-piperazine 
• 3268-74-4 2-chloro-N-(6-ethoxy-1,3-benzothiazol-2-yl)acetamide 

Relevant articles and documents

Synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazine

A series of thiazolyl-N-phenyl piperazines has been synthesised and tested for anti-inflammatory activity. Their RM values were determined as an expression of their lipophilicity. Theoretical calculation of their lipophilicity, as clog P and logPsk also performed. The effect of the synthesised compounds on inflammation, using the carrageenin induced mouse paw oedema model was studied. In general, the studied compounds were found to be potent anti-inflammatory agents (44-74.1%). Anti-inflammatory activity was influenced by some structural characteristics of the synthesised compounds. An attempt was made to correlate their biological activity with some physicochemical parameters using a quantitative structure-activity relationship approach (QSAR).