87207-08-7Relevant academic research and scientific papers
The Effect of a Cyano Group on the Thermodynamic Ease of Electron Removal from Hydrazines
Nelsen, Stephen F.,Parmelee, William P.,Rumack, Daniel T.
, p. 4219 - 4222 (1983)
Formal oxidation potentials relative to SCE are reported for several cyano-substituted hydrazines and their analogues with the cyano group replaced by a methyl group. ΔE*'was 0.83 V for 2-cyano- and 2-methyl-3-tert-butyl-2,3-diazabicycloheptane (1(CN) and 1(Me)), 0.35 V for trimethyl(cyanomethyl)hydrazine and ethyltrimethylhydrazine (3(CN) and 3(Me)), and 0.23 V for (β-cyanoethyl)trimethylhydrazine and propyltrimethylhydrazine (4(CN) and 4(Me)).The ESR spectrum of 1(CN)-d2 has nitrogen splittings of 17.2 and 7.7 G.The significance of these results is discussed.
Synthesis of p-aminobenzamides of aminopiperidazines as potential antiarrhythmic agents
Kornet,Abdul-Nabi Ali,Steinberg
, p. 967 - 971 (2007/10/02)
1,2-Dimethyl-4-aminopiperidazine (4), 1-(2-aminoethyl)-2-methylpiperidazine (11), 2-(2-aminoethyl)-3-methyl-2,3-diazabicyclo[2.2.1]heptane (16), and 1,2-dimethyl-3-aminomethylpiperidazine (21) have been synthesized. Amines 4, 11, and 16 were converted to the corresponding p-nitrobenzamides 7, 12, and 17. Catalytic reduction of the latter nitro derivatives gave the corresponding p-aminobenzamides 8, 13, and 18. For comparative studies, the acyclic analog, 4-amino-N-[2-(1,1,2-trimethylhydrazino)ethyl]benzamide (25) was also synthesized. Compounds 8, 13 and 25 which are analogs of procainamide were evaluated in the isolated cardiac Purkinje fiber preparation by measuring their effects on the action potential upstroke velocity.
