87207-85-0Relevant academic research and scientific papers
STUDY OF THE INFLUENCING FACTORS ON THE REACTION OF α-HALOGENATED KETIMINES WITH CYANIDE ION
Kimpe, Norbert De,Sulmon, Paul,Schamp, Niceas
, p. 567 - 586 (2007/10/02)
The reaction of α-halogenated ketimines with cyanide ion in various solvents leads to α-cyanoaziridines.The scope and limitations of this reaction have been studied by investigating reaction parameters such as the nitrogen substituent, the solvent, the so
Formation of α-Cyanoaziridines and 1-(Alkylamino)cyclopropanecarbonitriles by Cyanation of α-Halo Ketimines
De Kimpe, Norbert,Sulmon, Paul,Verhe, Roland,De Buyck, Laurent,Schamp, Niceas
, p. 4320 - 4326 (2007/10/02)
A new convenient synthesis of α-cyanoaziridines was developed by reaction of α-halo ketimines with cyanide in methanol or acetonitrile.Tertiary α-chloro ketimines with cyanide in methanol gave rise to a competitive reaction between α-cyanoaziridine formation and production of 1-(alkylamino)cyclopropanecarbonitriles, the latter being classified as a Favorskii rearrangement-type product.The scope and limitations of this reaction have been determined by investigation of reaction parameters such as the nitrogen substituent, the solvent, the inorganic cyanide, the carbon skeleton, and the nature of the α-halogen.
