872098-07-2Relevant academic research and scientific papers
A novel azetidinyl γ-lactam based peptide with a preference for β-turn conformation
Basak, Amit,Ghosh, Subhash C.,Das, Amit K.,Bertolasi, Valerio
, p. 4050 - 4052 (2005)
Synthesis of a new azetidinyl γ-lactam based peptides 1-3 with the preference for β-turn conformation is discussed. The tripeptide model compounds, namely the trans and the corresponding cis isomers, were studied by H NMR spectroscopy to measure the temperature coefficients of the two NH photons. It was observed that temperature coefficient NH of glycine was lowest, phenyl alanine-NH has higher temperature coefficient, and for both the cis tripeptides the temperature coefficients of shifts for all the NHs are above 5.0. The results show that the stereochemistry of β-lactam ring plays a key role in controlling the conformation of the peptides.
