872130-35-3

Upstream product

• 546-67-8 lead(IV) tetraacetate 
• 17554-22-2 N-benzyloxycarbonyl-L-phenylalanyl-L-threonine methyl ester 
• 23828-09-3 N-(benzyloxycarbonyl)-L-phenylalanyl-L-serine methyl ester 

Downstream Products

• 135924-38-8 Z-Phe-Gly(SPh)-OMe 
• 188302-22-9 N-benzyloxycarbonyl-L-phenylalanyl-DL-α-(ethylthio)glycine methyl ester 
• 708228-79-9 Z-Phe-Gly-OMe 
• 135924-21-9 Z-Phe-Gly(Br)-OMe 
• 122483-60-7 N-benzyloxycarbonyl-L-phenylalanyl-DL-α-chloroglycine methyl ester 

Relevant academic research and scientific papers

An improved protocol for the SmI2-promoted C-alkylation of peptides: Degradation and functionalization of serine residues in linear and cyclic peptides

The utility of the samarium diiodide promoted C-alkylation of peptides for the introduction of new side chains on peptide strands is dramatically enhanced by the initial oxidative degradation of serine residues in small peptides. In this way, cyclic pepti

Generation of α-Acetoxyglycine Residues within Peptide Chains: A New Strategy for the Modification of Oligopeptides

Seryl and threonyl peptides are converted into α-acetoxyglycyl peptides by treatment with lead tetraacetate.Reaction of these acetoxy derivatives or the more reactive α-chloroglycyl peptides with thiols, dithiols and carbohydrates allows the attachment of

CONVERSION OF SERINE AND THREONINE RESIDUES INTO α-ACYLOXY-, α-ALKYLTHIO-, AND α-HALOGENOGLYCINE MOIETIES: A NEW STRATEGY FOR THE MODIFICATION OF PEPTIDES

Selective modification of serine and threonine containing peptides is accomplished by oxidation with lead tetraacetate.Conversion of the derived α-acetoxyglycine derivative into α-alkylthio- and α-halogenoglycine residues offers a novel synthetic route to